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Updated: Feb 6, 2026
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Influenza A Virus Studies in a Mouse Model of Infection
Published on: September 7, 2017
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Animal Models in Influenza Research
Johanneke D Hemmink1,2, Catherine J Whittaker3, Holly A Shelton4,5
1Roslin Institute and R(D)SVS, University of Edinburgh, Midlothian, UK. Hanneke.Hemmink@roslin.ed.ac.uk.
Methods in Molecular Biology (Clifton, N.J.)
|August 29, 2018
Summary
Researchers explore animal models for studying influenza virus infection and transmission, detailing protocols for in vivo experiments. Selecting the right animal model, like mice or ferrets, is crucial for effective influenza research.
Area of Science:
- Virology
- Comparative Medicine
- Infectious Disease Research
Background:
- In vitro models are insufficient for studying complex influenza virus infection and transmission dynamics.
- Various animal models exist, each with unique advantages and limitations for influenza research.
Purpose of the Study:
- To describe standard protocols for in vivo experiments involving animal models of influenza.
- To guide the selection of appropriate animal models for influenza virus research.
Main Methods:
- Review of established animal models for influenza, including mice, guinea pigs, ferrets, pigs, and chickens.
- Description of standard operating procedures for in vivo experiments.
- Outline of pre-experiment requirements and sample processing techniques.
Main Results:
- Detailed protocols for utilizing specific animal models in influenza research are presented.
- Strengths and weaknesses of each animal model are discussed to aid in selection.
- Guidance on experimental setup and sample handling for in vivo influenza studies is provided.
Conclusions:
- Appropriate selection of animal models is essential for successful influenza virus research.
- Standardized protocols enhance the reliability and reproducibility of in vivo influenza studies.
- This work provides a foundational guide for researchers using animal models to study influenza.
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