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Viral Recombination

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.

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Related Experiment Video

Updated: May 29, 2025

Influenza A Virus Studies in a Mouse Model of Infection

Influenza A Virus Studies in a Mouse Model of Infection

Published on: September 7, 2017

Animal Models in Influenza Research.

Jie Zhou¹, Johanneke D Hemmink², Catherine J Whittaker^3,4

¹Department of Infectious Disease, Imperial College London, London, UK.

Methods in Molecular Biology (Clifton, N.J.)

|January 31, 2025

Summary

This summary is machine-generated.

Selecting the right animal model is crucial for influenza virus research. This guide details standard protocols for in vivo experiments, covering model selection and sample processing for common influenza models.

Keywords:

Aerosol Animal model Chicken Ferret Guinea pig Hamster Influenza Intranasal challenge (IN)Mouse Pig Swab Transmission

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Area of Science:

Virology
Comparative Medicine
Infectious Diseases

Background:

In vitro models are insufficient for studying influenza virus infection and transmission dynamics.
Various animal models are essential for advancing influenza research.
Understanding the strengths and weaknesses of each model is key for effective research.

Purpose of the Study:

To provide an overview of established animal model systems for influenza virus research.
To describe standard protocols for in vivo influenza experiments.
To guide the selection of appropriate animal models based on research needs.

Main Methods:

Review of established animal models for influenza, including mice, guinea pigs, hamsters, ferrets, pigs, and chickens.
Description of standard operating procedures for in vivo experiments.
Guidance on pre-experimental preparations and sample processing.

Main Results:

Identification of key animal models utilized in influenza research.
Outline of essential protocols for conducting in vivo influenza studies.
Emphasis on the comparative advantages and limitations of different models.

Conclusions:

Appropriate animal model selection is critical for successful influenza research.
Standardized protocols enhance the reliability and reproducibility of in vivo studies.
This resource aids researchers in choosing and utilizing animal models effectively for influenza virus investigation.