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New phenylpropanoids from Bulbophyllum retusiusculum
Yun-Shan Fang1,2, Ming-Hui Yang3, Le Cai4
1Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, China.
Archives of Pharmacal Research
|August 29, 2018
Summary
Two novel phenylpropanoids and phenylpropyl enantiomers were isolated from Bulbophyllum retusiusculum tubers. Compound 2 showed potent antifungal activity, while compound 3 exhibited moderate antibacterial properties.
Area of Science:
- Natural Product Chemistry
- Pharmacognosy
- Organic Chemistry
Background:
- Bulbophyllum retusiusculum is a plant species known for its potential medicinal properties.
- Phytochemical investigations are crucial for discovering new bioactive compounds.
Purpose of the Study:
- To isolate and characterize novel phenylpropanoids from Bulbophyllum retusiusculum tubers.
- To evaluate the antifungal and antibacterial activities of the isolated compounds.
Main Methods:
- Isolation and purification of compounds using chromatographic techniques.
- Structure elucidation through spectroscopic methods (NMR, MS).
- Determination of absolute configurations using electronic circular dichroism (ECD) and optical rotation.
Main Results:
- Two new phenylpropanoids (retusiusines A and B) and a pair of new phenylpropyl enantiomers ((±)-retusiusine C) were identified.
- Eight known compounds were also isolated and characterized.
- Compound 2 demonstrated potent antifungal activity against Candida albicans (16 μg/mL).
- Compound 3 displayed moderate antibacterial activity against Bacillus subtilis (64 μg/mL).
Conclusions:
- Bulbophyllum retusiusculum tubers are a source of novel phenylpropanoids with significant bioactivity.
- The isolated compounds, particularly retusiusine B and C, show promise as antifungal and antibacterial agents.
Keywords:
Absolute configurationAntibacterial activityAntifungal activityBulbophyllum retusiusculumPhenylpropanoidRetusiusine
