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Updated: Feb 6, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Two-year-old female with EBV-positive diffuse large B-cell lymphoma and subsequent CNS involvement with
Kari L Bjornard1, Vasiliki Leventaki2, Kim E Nichols1
1Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Abstract:
We describe a case of Epstein-Barr virus (EBV) positive, diffuse large B-cell lymphoma in a 2-year-old female who went on to develop relapsed/refractory central nervous system (CNS) disease, manifesting as cranial nerve neurolymphomatosis. Although her atypical presentation was thought to be associated with an immune deficiency, extensive work-up was negative. Despite subsequent treatment with third-party EBV-specific cytotoxic T-lymphocytes, she died of progressive disease. This case report raises questions as to whether tailored treatment approaches should be considered for atypical presentations of pediatric lymphoma (e.g., CNS and virus-associated).
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