Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Function Tests01:25

Pulmonary Function Tests

835
Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
835
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

461
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
461
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

3.2K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
3.2K
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

441
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
441
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

978
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
978
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

1.5K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Self-perceived burden and mental health outcomes in adults with osteogenesis imperfecta.

Journal of health psychology·2026
Same author

Sociodemographic and clinical predictors of resilience in individuals with osteogenesis imperfecta.

Disability and health journal·2026
Same author

C-Peptide Provides Critical Contextual Insight Into Elevated Glucose Values During Progression to Type 1 Diabetes.

Diabetes care·2026
Same author

Comparative analysis of clearing methods for 3D imaging of the vasculature in mineralized mouse tissues.

iScience·2026
Same author

Mechanical characterization of <i>Col1a1</i> <sup>+/-</sup> osteogenesis imperfecta bone revealed altered mechanical stiffness heterogeneity across scales.

Cell biomaterials·2026
Same author

A Case of Encephalocraniocutaneous Lipomatosis (ECCL) With Atypical Clinical Presentation Diagnosed on Molecular Testing: FGFR1 ECCL Tumor Risk.

American journal of medical genetics. Part A·2026
Same journal

Genetic Spectrum of Non-PTPN11 Variants in Noonan Syndrome and Related RASopathies: Findings From a Russian Cohort.

Clinical genetics·2026
Same journal

Phenotypic Characterization of Five Children With PACS1-NDD: Longitudinal Insights Into Development, Behavior, and Brain.

Clinical genetics·2026
Same journal

A Second Report of a Missense Variant in AMMECR1 Causing Midface Hypoplasia, Hearing Impairment, Elliptocytosis, and Nephrocalcinosis: Case Report and Literature Review.

Clinical genetics·2026
Same journal

From Pathogenicity to Mechanism: A Variant Interpretation Framework for Monogenic Epilepsy.

Clinical genetics·2026
Same journal

Biallelic Variants in ATP1A4 Are Associated with Oligoasthenoteratozoospermia and Male Infertility.

Clinical genetics·2026
Same journal

Diagnostic Yield and Clinical Impact of Comprehensive WES/WGS Testing Beyond Common Genetic Causes in Hereditary Optic Atrophy.

Clinical genetics·2026
See all related articles

Related Experiment Video

Updated: Feb 6, 2026

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
10:03

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Published on: June 27, 2025

793

A multicenter study to evaluate pulmonary function in osteogenesis imperfecta.

Allison Tam1, Shan Chen1, Evan Schauer1

  • 1Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.

Clinical Genetics
|August 29, 2018
PubMed
Summary
This summary is machine-generated.

Osteogenesis imperfecta (OI) patients, especially type III, show significantly reduced lung function (FVC, FEV1). Standard "percent predicted" values mask the true extent of pulmonary issues in OI patients.

Keywords:
lung diseaseosteogenesis imperfectapulmonary functionspirometry

More Related Videos

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

18.0K
Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice
09:40

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice

Published on: May 13, 2019

11.1K

Related Experiment Videos

Last Updated: Feb 6, 2026

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
10:03

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Published on: June 27, 2025

793
A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

18.0K
Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice
09:40

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice

Published on: May 13, 2019

11.1K

Area of Science:

  • Pulmonary Medicine
  • Genetics
  • Orthopedics

Background:

  • Pulmonary complications are a major cause of illness and death in osteogenesis imperfecta (OI).
  • Systematic evaluation of pulmonary function in OI patients is limited.
  • Osteogenesis imperfecta is a group of genetic disorders characterized by fragile bones.

Purpose of the Study:

  • To systematically evaluate pulmonary function in a large cohort of individuals with OI.
  • To assess the accuracy of standard pulmonary function metrics in OI.
  • To identify correlations between lung function and clinical variables in OI.

Main Methods:

  • Analysis of spirometry measurements (FVC, FEV1) in 217 individuals with OI.
  • Comparison of OI pulmonary function to normal population trends.
  • Use of linear mixed models to correlate lung function with clinical factors (mobility, bisphosphonate use, scoliosis).

Main Results:

  • Individuals with severe OI (type III) exhibit significantly reduced FVC and FEV1.
  • Standard "percent predicted" values underestimate pulmonary impairment in OI.
  • Correlations found between FEV1/FVC and mobility, bisphosphonate use, and scoliosis within OI subtypes.

Conclusions:

  • Pulmonary function is significantly impaired in OI, particularly in severe forms.
  • Current methods for assessing lung function in OI may not fully capture the disease burden.
  • Findings support the development of specific pulmonary endpoints for OI patient care and research.