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Development and cellular application of visible-light-controllable HNO releasers based on caged Piloty's acid
Mitsuyasu Kawaguchi1, Takuma Tani, Ryoma Hombu
1Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan. deco@phar.nagoya-cu.ac.jp.
Chemical Communications (Cambridge, England)
|August 29, 2018
Abstract:
Nitroxyl (HNO) is a gaseous molecule with unique pharmacological functions distinct from those of nitric oxide. Because HNO is highly reactive with biological molecules, spatiotemporally controllable HNO releasers are required. Herein, we report the first visible-light-controllable HNO releasers, based on caged Piloty's acid, and we demonstrate their applicability in living cells.