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Analytical quality goals-a review.

Bente Flatland¹, Melinda S Camus², Randolph M Baral³

¹Department of Biomedical & Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee.

Veterinary Clinical Pathology

|August 29, 2018

Summary

This summary is machine-generated.

Analytical quality goals ensure laboratory tests are clinically useful. Veterinary medicine currently lacks formalized goals, often relying on human or consensus-based standards, necessitating careful selection by individual labs.

Keywords:

Allowable total error TEA biological variation quality control quality requirement quality specification

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Area of Science:

Veterinary Laboratory Medicine
Clinical Pathology
Analytical Quality Management

Background:

Analytical quality goals define the performance needed for clinically useful laboratory tests.
Historically, focus has been on analytical error for quantitative methods, varying by concentration and species.
Formalized quality goal models exist in human medicine, but not yet in veterinary medicine.

Purpose of the Study:

To review the derivation and application of analytical quality goals.
To highlight challenges in establishing quality goals for veterinary diagnostics.
To provide guidance for veterinary laboratories in selecting appropriate quality goals.

Main Methods:

Literature review of analytical quality goal models.
Analysis of current practices in veterinary laboratory quality assessment.
Discussion of challenges and considerations for goal selection.

Main Results:

Veterinary laboratories commonly use human regulatory-based, consensus-based, or biologic variation-based goals.
There is a lack of formalized, veterinary-specific quality goal frameworks.
Selection of goals requires consideration of clinical utility, logistics, and financial feasibility.

Conclusions:

Formalization of quality goals in veterinary medicine is pending.
Individual veterinary laboratories must currently select goals based on specific needs and client requirements.
Prudent selection of quality goals is crucial for ensuring reliable veterinary diagnostics.