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Updated: Feb 6, 2026
06:51
A Preclinical Murine Model of Hepatic Metastases
Published on: September 27, 2014
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Hepatic Metastases From Prostatic Adenocarcinoma Without Elevated 18F-Choline Activity
Clinical Nuclear Medicine
|August 29, 2018
Summary
F-fluorocholine PET/CT may miss prostate cancer liver metastases. This pitfall, likely due to partial volume effects, requires careful interpretation alongside other imaging and pathology.
Area of Science:
- Nuclear Medicine
- Oncology
- Radiology
Background:
- Prostate cancer recurrence often requires advanced imaging for detection.
- F-fluorocholine (FCH) PET/CT is utilized for staging and detecting biochemical recurrence.
- Accurate localization of metastatic disease is crucial for treatment planning.
Observation:
- A 69-year-old man with biochemical recurrence of prostate cancer underwent FCH PET/CT.
- Two hepatic lesions showed no FCH uptake but increased in size on serial imaging.
- MRI revealed peripheral contrast enhancement in these lesions, suggestive of metastasis.
Findings:
- Histopathology confirmed the hepatic lesions as prostate adenocarcinoma metastasis.
- FCH PET/CT demonstrated a lack of radiotracer uptake in the liver metastasis.
- This negative finding on FCH PET/CT is attributed to a partial volume effect.
Implications:
- This case illustrates a potential pitfall in FCH PET/CT interpretation for prostate cancer.
- Necrotic centers and high liver uptake may obscure metastatic lesions on FCH PET/CT.
- Correlating FCH PET/CT findings with MRI and histopathology is essential for accurate diagnosis.
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