Related Experiment Video

Updated: Feb 6, 2026

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

35.1K

Cellular Senescence: The Sought or the Unwanted?

Yu Sun1, Jean-Philippe Coppé2, Eric W-F Lam3

  • 1Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China; Department of Medicine and Veterans Affairs Puget Sound Health Care Systems (VAPSHCS), University of Washington, Seattle, WA 98195, USA.

Trends in Molecular Medicine
|August 30, 2018
PubMed

Insights

Cellular senescence causes irreversible cell arrest and a secretory phenotype (SASP) linked to aging and cancer. Targeting SASP and senescent cells offers new precision medicine strategies.

Area of Science:

  • Oncology
  • Aging Research
  • Cell Biology

Background:

  • Cellular senescence is a state of irreversible cell-cycle arrest.
  • Senescence features a senescence-associated secretory phenotype (SASP) with implications in aging and cancer.
  • Cellular senescence exhibits a dual role in human cancer, acting as both a tumor suppressor and a promoter.

Purpose of the Study:

  • To review recent discoveries in senescence and SASP biology.
  • To highlight the potential of targeting senescent cells and SASP in cancer therapy.
  • To explore the role of senescence in aging-related pathologies and malignancies.

Main Methods:

  • Literature review of recent senescence research.
  • Analysis of SASP biology and its role in cancer.
  • Discussion of emerging therapeutic strategies targeting senescent cells.

Main Results:

  • Senescence is a complex process with both beneficial and detrimental effects in cancer.
  • The SASP contributes to aging-related diseases and cancer progression.
  • Senescent cells and SASP are implicated in various malignancies.

Conclusions:

  • Targeting senescent cells and suppressing SASP are promising avenues for precision medicine.
  • Understanding senescence and SASP is crucial for developing novel cancer therapies.
  • Further research into senolytic agents and SASP inhibitors is warranted for clinical application.
Keywords:
aging-related pathologycancercellular senescencesenescence-associated secretory phenotypesenolyticstherapy-induced senescence

More Related Videos

Induction and Validation of Cellular Senescence in Primary Human Cells08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

18.1K
A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.6K

Related Concept Videos

Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.4K
Cellular Differentiation00:57

Cellular Differentiation

How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
5.4K
Cellular Respiration01:18

Cellular Respiration

Cellular respiration is a crucial metabolic process through which cells obtain energy from organic substances, mainly glucose, to produce adenosine triphosphate (ATP). This process includes the oxidation of substrates and the transfer of electrons to a separate electron acceptor, facilitating ATP synthesis through a sequence of biochemical reactions.Glycolysis: The Initial StepGlycolysis is the first stage of cellular respiration, occurring in the cytoplasm of both prokaryotic and eukaryotic...
2.0K
Introduction to Cellular Respiration01:22

Introduction to Cellular Respiration

Organisms harvest energy from food, but this energy cannot be directly used by cells. Cells convert the energy stored in nutrients into a more usable form: adenosine triphosphate (ATP).
ATP stores energy in chemical bonds that can be quickly released when needed. Cells produce energy in the form of ATP through the process of cellular respiration. Although much of the energy from cellular respiration is released as heat, some of it is used to make ATP.
During cellular respiration, several...
189.6K
Cellular Membranes and Drug Transport01:24

Cellular Membranes and Drug Transport

Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
1.6K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
16.5K