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Vertebral Artery Occlusive Disease: Data from the Angiographically Confirmed Vertebral Artery Disease Registry
Adnan I Qureshi1, Sehar Babar2, Omar Saeed3
1Zeenat Qureshi Stroke Institute, St. Cloud, Minnesota;.
Insights
Vertebral artery occlusive disease (VAOD) is linked to hypertension, diabetes, coronary artery disease, and smoking. More severe stenosis and bilateral artery involvement correlate with ischemic symptoms in patients with VAOD.
Area of Science:
- Vascular Medicine
- Neurology
- Cardiology
Background:
- Vertebral artery occlusive disease (VAOD) affects adult patients.
- Understanding VAOD characteristics and risk factors is crucial.
Purpose of the Study:
- Identify demographic, clinical, and angiographic features of VAOD.
- Determine risk factors associated with VAOD occurrence.
Main Methods:
- Patient data and angiographic features were collected using predefined criteria.
- Controls were sourced from National Health and Nutrition Examination Surveys.
- Stepwise logistic regression analyzed risk factor effects on VAOD.
Main Results:
- 56 adult patients with VAOD were studied (mean age 65.4 years, 44.6% women).
- Stenosis ranged from moderate (37.5%) to severe (16.1%), with 46.4% having occlusion.
- Hypertension, diabetes, coronary artery disease, and smoking were significantly associated with VAOD.
Conclusions:
- Symptomatic VAOD was linked to stenosis severity and bilateral artery involvement.
- Hypertension, diabetes, coronary artery disease, and smoking are significant risk factors for VAOD.
Background:
We performed this study to identify demographic, clinical, and angiographic characteristics of adult patients with angiographically confirmed vertebral artery occlusive disease (VAOD) and associated risk factors.
Methods:
The demographic and clinical characteristics, and angiographic features were ascertained using predefined criteria. Controls were selected from the National Health and Nutrition Examination Surveys matched according to age, sex, and ethnicity. A stepwise logistic regression for odds ratio (OR) was performed to identify the effects of risk factors on occurrence of VAOD.
Results:
Of 56 patients with VAOD (mean age ± standard deviation [SD]; 65.4 ± 11.7years, 44.6% women), 37.5% were classified as suffering from moderate stenosis (50%-69%), 16.1% from severe stenosis (70%-99%), and 46.4% from occlusion of at least 1 vertebral artery. There was a significantly higher severity of stenosis (percentage with SD; 88.1 ± 16.5 versus 75.4 ± 20.8, P = .02) and frequency of bilateral vertebral artery disease in patients with ischemic symptoms (40.9% versus 8.8%, P = .004). In the multivariate analysis, hypertension (OR 3.0; 95% confidence interval [CI], 1.4-6.5), diabetes mellitus (OR 2.5; 95% CI, 1.4-4.6), coronary artery disease (OR 3.2; 95% CI, 1.7-6.0), and active cigarette smoking (OR 3.1; 95% CI, 1.5-6.3) were significantly associated with vertebral artery disease.
Conclusions:
Severity of stenosis and bilateral involvement were associated with symptomatic VAOD. Hypertension, diabetes mellitus, coronary artery disease, and active cigarette smoking were associated with occurrence of VAOD.
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