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Updated: Feb 6, 2026

A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures
Published on: March 18, 2021
[Progress in synaptic mechanism in epileptogenesis]
Xiuzhen Xiao1, Yuanhan Ouyang2, Zhi Song2
1Department of Nursing, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Abstract:
Recurrent seizures lead to abnormal expression of synaptic proteins, reorganization of synapse and formation of abnormal neuron network. Recently, it is identified that the synaptic proteins are involved in epileptogenesis. The abnormal expression of several synaptic regulatory proteins and postsynaptic membrane receptor proteins may result in epilepsy. The ion channels usually are the action target of most antiepileptic drugs. However, carbamazepine and zonisamide may interact with syntaxin and/or soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex to exert its function of anti-epilepsy. The synaptic vesicle protein 2A is the action target for new anti-epileptic drugs, including levetiracetam, brivaracetam and seletracetam.
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