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Tibetan Tea Alleviates the Intestinal Dysfunction in Sleep-Deprived Mice Through Regulating Oxidative Stress and
Ge Liang1, Wen Zheng1, Yaru Dai2
1Department of Gastroenterology, Metabolomics and Proteomics Technology Platform, West China Hospital, Sichuan University, Chengdu, China.
Molecular Nutrition & Food Research
|May 12, 2025
Summary
Tibetan tea extract (TTE) alleviates sleep deprivation-induced intestinal inflammation by reducing oxidative stress and restoring gut barrier function. TTE also positively modulates gut microbiota and metabolic disturbances, suggesting its therapeutic potential.
Area of Science:
- Gastroenterology and Nutrition
- Microbiology and Immunology
Background:
- Sleep deprivation (SD) disrupts intestinal homeostasis, leading to increased oxidative stress and inflammation.
- Tibetan tea is explored for its anti-inflammatory properties, but its effects on sleep deprivation-induced intestinal issues are unknown.
Purpose of the Study:
- To investigate the protective effects of Tibetan tea water-soluble extract (TTE) against intestinal dysfunction caused by sleep deprivation in mice.
Main Methods:
- Mice underwent sleep deprivation with or without TTE supplementation.
- Assessed physiological parameters, inflammatory cytokines, oxidative stress markers (ROS), intestinal barrier integrity (goblet cells, MUC2, tight junctions), gut microbiota composition, and metabolic profiles.
Main Results:
- Sleep deprivation increased ROS, pro-inflammatory cytokines, and intestinal injury (reduced goblet cells, MUC2, tight junctions).
- TTE supplementation reversed these effects, improving mucosal integrity.
- TTE modulated gut microbiota, increased beneficial bacteria producing short-chain fatty acids (SCFAs), and restored metabolic disturbances.
Conclusions:
- Tibetan tea extract ameliorates sleep deprivation-induced intestinal dysfunction by reducing oxidative stress, enhancing intestinal barrier function, and regulating the gut microbiome.
- Tibetan tea shows potential as a dietary intervention for managing intestinal inflammation associated with sleep deprivation.
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