[Family aggregation of hepatocarcinoma--preliminary analysis]

A pedigree study was carried out in families with hepatocarcinoma (HCC) in Qidong county. The results showed that the incidence of families with familial history of HCC was 41.59% (443/1065). By means of test for Fitness of Binomial Distribution, it was found that HCC had an evident tendency of familial aggregation (P less than 0.01). In the high risk families, the average death age of patients with HCC in filial generation was younger (38.92 years old) than that of people who die of HCC in Qidong county (49.26 years old). The age at which siblings had HCC was often similar: 31.63%, with age-difference less than or equal to 2 years and 61.22%, less than or equal to 5 years. Whether the members of high risk families lived together or not, the incidence of HCC was alike (P greater than 0.05). These results suggest that the role of genetic factors in the etiology of HCC should not be neglected.