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Updated: Feb 6, 2026
08:51
Quantification of Coenzyme A in Cells and Tissues
Published on: September 27, 2019
8.9K
Coenzyme Q10 in acute influenza
Maureen Chase1, Michael N Cocchi1,2, Xiaowen Liu1
1Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Influenza and Other Respiratory Viruses
|August 30, 2018
Summary
Acute influenza infection is linked to lower CoQ10 levels. These Coenzyme Q10 (CoQ10) levels also showed weak correlations with certain inflammatory biomarkers in patients.
Area of Science:
- Biochemistry
- Immunology
- Infectious Diseases
Background:
- Coenzyme Q10 (CoQ10) is vital for cellular energy production and acts as an antioxidant.
- Influenza infections can trigger significant systemic inflammation and oxidative stress.
Purpose of the Study:
- To investigate if acute influenza infection leads to CoQ10 depletion compared to healthy individuals.
- To explore associations between CoQ10 levels, illness severity, and inflammatory markers in influenza patients.
Main Methods:
- Serum CoQ10 concentrations were measured in 50 influenza patients and 29 healthy controls.
- Statistical analyses included Wilcoxon rank sum test and Spearman correlation coefficient.
- Data were collected from a single urban tertiary care center over three influenza seasons.
Main Results:
- Influenza patients exhibited significantly lower CoQ10 levels (0.53 μg/mL) than controls (0.72 μg/mL).
- A higher percentage of influenza patients (48%) had low CoQ10 (<0.5 μg/mL) compared to controls (7%).
- Weak correlations were observed between CoQ10 and IL-2, TNF-alpha, and VEGF, but not IL-6, IL-10, VCAM, or illness severity.
Conclusions:
- Acute influenza infection is associated with a significant depletion of Coenzyme Q10.
- CoQ10 levels demonstrated weak correlations with specific inflammatory biomarkers during influenza infection.
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