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Related Concept Videos

Systematic Error: Methodological and Sampling Errors01:15

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Related Experiment Video

Updated: Feb 6, 2026

Creation of Patient-Specific Silicone Cardiac Models with Applications in Pre-surgical Plans and Hands-on Training
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Pre-analytic error: A significant patient safety risk.

Yael K Heher1, Yigu Chen1, Paul A VanderLaan1

  • 1Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.

Cancer Cytopathology
|August 30, 2018
PubMed
Summary

Ancillary testing in cytopathology enhances specimen value but introduces patient safety risks. A team-based approach focusing on pre-analytic processes is crucial for error reduction and safety improvement.

Keywords:
cytologyimprovementpre-analyticqualityrisksafetysend-outtesting

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Area of Science:

  • Cytopathology
  • Medical Diagnostics
  • Laboratory Medicine

Background:

  • Ancillary testing in cytopathology has significantly expanded, increasing the clinical utility of minimally invasive specimen collection.
  • This expansion has introduced new patient safety risks due to the complexity of the testing landscape.

Purpose of the Study:

  • To highlight the emerging patient safety risks associated with ancillary cytopathology testing.
  • To emphasize the importance of addressing pre-analytic factors and promoting a collaborative approach to mitigate these risks.

Main Methods:

  • Review of current practices and challenges in ancillary cytopathology testing.
  • Analysis of pre-analytic workflow steps, including test ordering, specimen collection, transport, accessioning, and processing.
  • Discussion of risks associated with centralized reference laboratory testing.

Main Results:

  • Pre-analytic factors are the primary source of errors in pathology.
  • Decentralized testing and increased reliance on external laboratories introduce additional safety concerns.
  • Systemic issues and shared responsibility are key to managing safety risks.

Conclusions:

  • Improving pre-analytic processes through a collaborative, team-based approach is essential for enhancing patient safety in cytopathology.
  • Addressing operational steps and stakeholder engagement can minimize errors and risks in ancillary testing.
  • A proactive strategy is needed to navigate the complexities of modern cytopathology diagnostics.