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Updated: Feb 6, 2026
07:16
Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
Published on: March 14, 2014
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ANO7 is associated with aggressive prostate cancer.
Elina Kaikkonen1, Tommi Rantapero2, Qin Zhang3,4
1Institute of Biomedicine, University of Turku, Turku, Finland.
International Journal of Cancer
|August 30, 2018
Summary
Genetic variants in the ANO7 gene are linked to prostate cancer (PrCa) risk and aggressiveness. High ANO7 expression correlates with poor survival, identifying ANO7 as a potential PrCa susceptibility gene.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Prostate cancer (PrCa) is a heritable malignancy with a need for biomarkers predicting disease outcome.
- Previous research identified predisposing signals near the ANO7 gene at 2q37.
Purpose of the Study:
- To investigate the association between the ANO7 gene and PrCa risk and aggressiveness.
- To identify germline biomarkers for predicting PrCa disease outcome.
Main Methods:
- Sequencing of ANO7 in tumors and patient samples.
- Genotyping of pathogenic variants in 1769 PrCa patients and 1711 controls.
- Expression analysis of ANO7 in relation to PrCa aggressiveness using various databases and cohorts.
- Association analyses (case-control, aggressive vs. nonaggressive) and survival analyses.
Main Results:
- Variant rs77559646 showed association with PrCa risk (OR 1.40) and aggressive PrCa (p=0.04), and acts as an eQTL for ANO7.
- Variant rs148609049 was linked to shorter survival (HR 1.56).
- High ANO7 mRNA expression was independently associated with poor survival (HR 18.4).
Conclusions:
- ANO7 genotypes correlate with gene expression and biochemical relapse.
- ANO7 is a potential PrCa susceptibility gene.
- Elevated ANO7 expression is linked to increased PrCa severity and poorer patient outcomes.
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