Related Experiment Video

Updated: Feb 6, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

1.3K

Serum Apelin and Obesity-Related Complications in Egyptian Children

Maged A El Wakeel1, Ghada M El-Kassas1, Alyaa H Kamhawy1

  • 1Child Health Department, Medical Division, National Research Centre, Cairo, Egypt.

Open Access Macedonian Journal of Medical Sciences
|August 31, 2018
PubMed

Insights

Serum apelin levels are higher in obese children and linked to metabolic complications like insulin resistance and hypertension. Fasting blood glucose is a key predictor of apelin levels in this population.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Syndrome Research
  • Adipokine Signaling

Background:

  • Childhood obesity is a global health concern.
  • Adipocytes release adipokines that regulate metabolism.
  • Apelin is an adipokine implicated in metabolic processes.

Purpose of the Study:

  • To investigate the association between serum apelin and childhood obesity.
  • To explore the relationship between apelin and obesity-related complications such as hypertension and hyperglycemia.

Main Methods:

  • Study included 50 obese and 31 non-obese children.
  • Assessed anthropometric measurements, blood pressure, lipid profile, serum insulin, fasting blood glucose (FBG), HOMA-IR, and serum apelin.
  • Compared parameters between obese and non-obese groups.

Main Results:

  • Obese children exhibited elevated HbA1c, FBG, insulin, HOMA-IR, cholesterol, triglycerides, LDL, and DBP Z-scores.
  • Serum apelin levels were significantly higher in obese children.
  • Apelin positively correlated with BMI Z-Score, DBP Z-Score, cholesterol, TG, insulin, FBG, and HOMA-IR.

Conclusions:

  • Apelin may play a role in the development of obesity-related health issues in children.
  • Findings suggest apelin's involvement in insulin resistance and hypertension.
  • Apelin may contribute to the risk of metabolic syndrome in pediatric obesity.
Abstract

Keywords:
ApelinChildrenMetabolic syndromeObesity

More Related Videos

Eye Tracking Young Children with Autism09:03

Eye Tracking Young Children with Autism

Published on: March 27, 2012

46.6K
Studying Brain Function in Children Using Magnetoencephalography08:00

Studying Brain Function in Children Using Magnetoencephalography

Published on: April 8, 2019

9.6K

Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.3K
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
865
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
875
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.4K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.4K
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
268