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03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
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Anal squamous cell carcinoma: are we improving outcomes?
Alicia Mackowski1, Michael Levitt2, Gregory Makin2
1Department of General Surgery, Royal Perth Hospital, Perth, Western Australia, Australia.
ANZ Journal of Surgery
|August 31, 2018
Summary
This study reviewed anal squamous cell carcinoma (SCC) treatment outcomes, finding chemoradiation (CRT) effective but highlighting the need for novel approaches due to persistent recurrence rates.
Area of Science:
- Oncology
- Surgical Oncology
- Radiation Oncology
Background:
- Anal squamous cell carcinoma (SCC) is a rare but serious malignancy.
- Understanding treatment outcomes for anal SCC is crucial for patient management.
Purpose of the Study:
- To review the institutional experience with anal SCC over a 10-year period.
- To evaluate the effectiveness of current treatment modalities for anal SCC.
Main Methods:
- Retrospective review of patients with anal SCC (2006-2016).
- Analysis of treatment approaches including wide local excision and chemoradiation (CRT).
- Outcomes assessed included recurrence, overall survival, and survival post-salvage surgery.
Main Results:
- Forty-seven patients were identified with a median follow-up of 2.73 years.
- Five-year recurrence and overall survival rates were 35.8% and 65.4%, respectively.
- Locoregional failure was common, with salvage surgery yielding limited success.
Conclusions:
- Chemoradiation (CRT) remains an effective treatment for anal cancer.
- Current treatment strategies for anal SCC have seen little advancement in decades.
- Novel therapeutic approaches are necessary to improve patient outcomes in anal SCC.
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