Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Axonal stimulation for end-plate jitter studies.

J V Trontelj, M Mihelin, J M Fernandez

    Journal of Neurology, Neurosurgery, and Psychiatry
    |June 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Between genetics and biology. Is ENMG useful in peripheral neuropathy diagnosis and management?

    Revue neurologique·2016
    Same author

    Peripheral neuropathy caused by severe hypothermia.

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2012
    Same author

    Reference values for F wave parameters in healthy 3-20 year old subjects.

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2010
    Same author

    The difficulty in confirming clinical diagnosis of myasthenia gravis in a seronegative patient: a possible neurophysiological approach.

    Neuromuscular disorders : NMD·2009
    Same author

    Charcot-marie-tooth disease with cerebellar atrophy.

    Journal of clinical neuromuscular disease·2008
    Same author

    Quantitative sensory testing in patients with polyneuropathy and healthy individuals.

    Acta neurologica Scandinavica. Supplementum·2008
    Same journal

    Clinical outcomes of conservative, endovascular and microsurgical management of unruptured giant intracranial aneurysms: 3-year follow-up of the prospective, multinational Giant Intracranial Aneurysm Registry.

    Journal of neurology, neurosurgery, and psychiatry·2026
    Same journal

    Global epidemiology of amyotrophic lateral sclerosis: a systematic review and meta-analysis.

    Journal of neurology, neurosurgery, and psychiatry·2026
    Same journal

    Diagnostic accuracy of a two-cut-off approach using the FAQ/MMSE ratio and FAQ for clinical preselection of patients for anti-amyloid therapy.

    Journal of neurology, neurosurgery, and psychiatry·2026
    Same journal

    Cancer risk and mortality in patients with multiple sclerosis in Finland: a retrospective population-based cohort study.

    Journal of neurology, neurosurgery, and psychiatry·2026
    Same journal

    Visuospatial working memory in Huntington's disease: behavioural and structural brain correlates.

    Journal of neurology, neurosurgery, and psychiatry·2026
    Same journal

    Characteristics and outcomes in electric scooter-related traumatic brain injuries in Helsinki.

    Journal of neurology, neurosurgery, and psychiatry·2026
    See all related articles

    This study compared two methods for measuring neuromuscular jitter, finding axonal stimulation reliable for routine use. It offers new upper normal limits for jitter in the extensor digitorum communis muscle.

    Area of Science:

    • Neuroscience
    • Electromyography
    • Motor Neuron Diseases

    Background:

    • Accurate measurement of neuromuscular jitter is crucial for diagnosing disorders affecting the neuromuscular junction.
    • Standard single-fiber electromyography (EMG) methods for jitter measurement can be influenced by factors like interdischarge intervals and split muscle fibers.
    • Developing reliable alternative methods is essential for precise clinical assessment.

    Purpose of the Study:

    • To compare neuromuscular jitter measurements obtained through standard voluntary activation with those from intramuscular electrical stimulation of motor axons.
    • To evaluate the reliability and ease of use of axonal stimulation for routine neuromuscular jitter estimation.
    • To establish new upper normal limits for neuromuscular jitter in the extensor digitorum communis muscle.

    Related Experiment Videos

    Main Methods:

    • Single-fiber EMG was used in normal subjects to compare jitter measurements from voluntary muscle activation versus direct intramuscular electrical stimulation of motor axons.
    • The study analyzed the impact of interdischarge interval and potential split muscle fiber recognition on jitter measurements.
    • Mean consecutive difference (MCD) was calculated for both methods.

    Main Results:

    • Axonal stimulation effectively bypasses interdischarge interval-dependent jitter and issues with split muscle fiber recognition.
    • The mean MCD with axonal stimulation was only slightly lower (5.2 microseconds, 8% higher than theoretically expected) than with voluntary activation.
    • Suggested upper normal limits for jitter in the extensor digitorum communis are 40 microseconds (individual fibers) and 25 microseconds (mean of 30 fibers).

    Conclusions:

    • Intramuscular electrical stimulation of motor axons is a reliable and relatively easy method for routine neuromuscular jitter estimation.
    • Careful attention to time measurement resolution (better than 2 microseconds) is necessary to avoid misinterpreting low jitter.
    • The study provides updated, clinically relevant upper normal limits for neuromuscular jitter in a key muscle group.