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Coronary Artery Disease I: Introduction

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Related Experiment Video

Updated: Feb 5, 2026

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

ST segment elevation myocardial infarction with normal coronary arteries.

Siddharthan Deepti¹, Raghav Bansal¹, Sandeep Singh¹

¹Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India.

|September 1, 2018

Summary

A patient receiving 5-fluorouracil chemotherapy experienced myocardial infarction. Coronary angiography revealed no obstructive lesions, suggesting vasospasm as the likely cause of the heart attack.

Keywords:

5-fluorouracil MINOCA cardiotoxicity chemotherapy

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Area of Science:

Cardiology
Oncology
Pharmacology

Background:

A middle-aged patient with metastatic colon adenocarcinoma on 5-fluorouracil (5-FU) chemotherapy presented with acute chest pain.
Electrocardiogram (ECG) showed ST-segment elevation, and cardiac troponin levels were elevated, indicating myocardial infarction.

Purpose of the Study:

To investigate the underlying mechanism of myocardial infarction in a patient undergoing 5-FU chemotherapy.

Main Methods:

Clinical presentation, ECG, cardiac biomarkers, coronary angiography, and echocardiography were utilized.
The patient received standard medical therapy for acute coronary syndrome.

Main Results:

Coronary angiography demonstrated no significant obstructive coronary artery disease.
The patient's symptoms resolved, and repeat ECG showed improvement.

Conclusions:

Coronary artery vasospasm is a potential mechanism for myocardial infarction in patients receiving 5-FU chemotherapy.
This case highlights the importance of considering non-obstructive causes of myocardial infarction in this patient population.