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Ticagrelor Removal From Human Blood

George O Angheloiu1,2,3, Gabriel B Gugiu4, Cristian Ruse5

  • 1Massachusetts Institute of Technology, Cambridge, Massachusetts.

JACC. Basic to Translational Science
|September 1, 2018
PubMed

The authors devised an efficient method for ticagrelor removal from blood using sorbent hemadsorption. Ticagrelor removal was measured in 2 sets of in vitro experiments. The first set was a first-pass experiment using bovine serum albumin (BSA) solution pre-incubated with ticagrelor, whereas the second set, performed in a recirculating manner, used human blood mixed with ticagrelor. Removal of ticagrelor from BSA solution reached values >99%. The peak removal rate was 99% and 94% from whole blood and 99.99% and 90% from plasma during 10 h and 3 to 4 h of recirculating experiments, respectively. In conclusion, hemadsorption robustly removes ticagrelor from BSA solution and human blood samples.

Keywords:
BSA, bovine serum albuminCABG, coronary artery bypass graftP2Y12b.i.d., twice a dayconcentrationdrugplateletremovalsorbentticagrelor

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