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Improved Method for the Preparation of a Human Cell-based, Contact Model of the Blood-Brain Barrier
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Ticagrelor Removal From Human Blood.

George O Angheloiu1,2,3, Gabriel B Gugiu4, Cristian Ruse5

  • 1Massachusetts Institute of Technology, Cambridge, Massachusetts.

JACC. Basic to Translational Science
|September 1, 2018
PubMed
Summary

Sorbent hemadsorption efficiently removes ticagrelor from blood. This method achieved over 99% ticagrelor removal in vitro, demonstrating its effectiveness for potential therapeutic applications.

Keywords:
BSA, bovine serum albuminCABG, coronary artery bypass graftP2Y12b.i.d., twice a dayconcentrationdrugplateletremovalsorbentticagrelor

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Area of Science:

  • Pharmacology
  • Biomedical Engineering
  • Toxicology

Background:

  • Ticagrelor is an antiplatelet medication.
  • Efficient methods for drug removal from blood are crucial for managing overdoses or toxicity.
  • Hemadsorption is a potential extracorporeal technique for substance removal.

Purpose of the Study:

  • To develop and evaluate an efficient sorbent hemadsorption method for ticagrelor removal from blood.
  • To quantify the efficacy of hemadsorption in removing ticagrelor from both artificial solutions and human blood samples.

Main Methods:

  • In vitro experiments were conducted using bovine serum albumin (BSA) solution and human blood.
  • Two experimental setups were used: a first-pass experiment and a recirculating system.
  • Ticagrelor removal was measured using the sorbent hemadsorption technique.

Main Results:

  • Hemadsorption achieved >99% ticagrelor removal from BSA solution.
  • In recirculating experiments, peak ticagrelor removal from whole blood was 99% and 94% over 10 hours.
  • Peak removal from plasma was 99.99% and 90% over 3-4 hours.

Conclusions:

  • Sorbent hemadsorption is a robust and effective method for removing ticagrelor.
  • The technique demonstrates high efficiency in both artificial solutions and human blood matrices.
  • Hemadsorption shows promise as a therapeutic strategy for ticagrelor removal.