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Related Experiment Videos

The curve-shift paradigm in self-stimulation.

E Miliaressis, P P Rompre, P Laviolette

    Physiology & Behavior
    |January 1, 1986
    PubMed
    Summary
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    Neuroleptics like chlorpromazine and pimozide reduced the reinforcing effects of electrical brain stimulation in rats. Other factors interfering with lever pressing also altered stimulation efficacy, impacting response rates.

    Area of Science:

    • Neuroscience
    • Behavioral Pharmacology

    Background:

    • Operant conditioning is used to study reward and reinforcement.
    • Electrical brain stimulation serves as a powerful reinforcer in animal models.
    • Neuroleptics and behavioral manipulations can modulate the reinforcing efficacy of stimuli.

    Purpose of the Study:

    • To investigate the effects of neuroleptics (pimozide, chlorpromazine) and behavioral manipulations on the reinforcing efficacy of electrical brain stimulation in rats.
    • To analyze rate-frequency functions and determine changes in reinforcement parameters.

    Main Methods:

    • Rats were trained to press a lever for rewarding electrical stimulation.
    • Rate-frequency functions were assessed under different drug conditions (pimozide, chlorpromazine) and behavioral manipulations (methocarbamol, increased lever weight, F1 schedule).

    Related Experiment Videos

  • Changes in reinforcing efficacy were quantified using theta 0 and M50 indices.

    • Main Results:

    • Low doses of chlorpromazine and pimozide caused parallel shifts in rate-frequency functions, indicating reduced reinforcing efficacy.
    • Behavioral manipulations decreased asymptotic rates and caused lateral shifts in the functions.
    • M50 index showed larger artifactual changes in efficacy compared to theta 0 for behavioral manipulations, due to asymptote shifts.

    Conclusions:

    • Neuroleptics decrease the reinforcing efficacy of electrical stimulation by altering the rate-frequency relationship.
    • Behavioral manipulations can also affect reinforcement efficacy, with M50 being more sensitive to asymptote shifts.
    • These findings provide insights into the neurobiological and behavioral mechanisms underlying reinforcement.