Related Experiment Video
Updated: Feb 5, 2026
05:39
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
Published on: May 16, 2025
672
A Pilot Study Characterizing Factors in Adherence to Cutaneous Lupus Treatment.
Teresa Ro1, Rechelle Z Tull1, Leah A Cardwell1
11 Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Journal of Cutaneous Medicine and Surgery
|September 1, 2018
Summary
Patient adherence to topical corticosteroids for cutaneous lupus erythematosus (CLE) is suboptimal and decreases over time. Improving adherence may be more valuable than developing new treatments for this autoimmune skin condition.
Area of Science:
- Dermatology
- Autoimmune Diseases
- Pharmacology
Background:
- Cutaneous lupus erythematosus (CLE) is an autoimmune skin disease.
- Topical corticosteroids are a primary treatment for CLE.
- Treatment nonadherence, often due to irritation or inconvenience, can lead to treatment failure.
Purpose of the Study:
- To assess topical medication adherence in patients with CLE.
- To identify factors influencing adherence in CLE patients.
Main Methods:
- A single-center, open-label pilot study was conducted.
- Adherence to topical medication was evaluated in CLE patients.
Main Results:
- Adherence to topical medications in CLE patients was found to be suboptimal.
- Adherence tended to decline over the study period.
- Shorter treatment duration and higher perceived disease severity correlated with better adherence.
Conclusions:
- Topical medication adherence in CLE is a significant issue.
- Strategies to improve adherence could enhance treatment outcomes.
- Enhancing adherence may be as critical as developing novel therapies for CLE.
Related Concept Videos
01:21Pilot and Numeric Relaying
492
Pilot relaying is a type of differential protection used in power systems. It compares electrical quantities at the terminals of equipment via a communication channel instead of direct relay interconnection. This method is essential for transmission lines where the terminals are far apart, typically up to 80 km for lines with 69 to 115 kV ratings. Four types of communication channels are used for pilot relaying:
492
02:16Transcription Factors
82.8K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.8K
04:01Factors Affecting Solubility
37.2K
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
37.2K
02:35Transcription Elongation Factors
14.0K
Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
14.0K
01:19Factors Affecting Drug Distribution: Miscellaneous Factors
994
Drug distribution in the human body is a complex process influenced by various individual factors, including age, pregnancy, obesity, diet, body water composition, pH levels, and specific disease conditions.
Age plays a significant role due to differences in body composition among different age groups. Infants, for instance, have a higher proportion of total body water and lower albumin levels, a protein that binds drugs in the bloodstream. This unique composition in infants enhances the...
Age plays a significant role due to differences in body composition among different age groups. Infants, for instance, have a higher proportion of total body water and lower albumin levels, a protein that binds drugs in the bloodstream. This unique composition in infants enhances the...
994
03:08Electrolytes: van't Hoff Factor
36.9K
Colligative Properties of Electrolytes
The colligative properties of a solution depend only on the number, not on the identity, of solute species dissolved. The concentration terms in the equations for various colligative properties (freezing point depression, boiling point elevation, osmotic pressure) pertain to all solute species present in the solution. Nonelectrolytes dissolve physically without dissociation or any other accompanying process. Each molecule that dissolves yields one...
The colligative properties of a solution depend only on the number, not on the identity, of solute species dissolved. The concentration terms in the equations for various colligative properties (freezing point depression, boiling point elevation, osmotic pressure) pertain to all solute species present in the solution. Nonelectrolytes dissolve physically without dissociation or any other accompanying process. Each molecule that dissolves yields one...
36.9K