Related Experiment Video

Updated: Feb 5, 2026

A Modified Sonographic Algorithm for Image Acquisition in Life-Threatening Emergencies in the Critically Ill Newborn
11:27

A Modified Sonographic Algorithm for Image Acquisition in Life-Threatening Emergencies in the Critically Ill Newborn

Published on: April 7, 2023

7.4K

Life-threatening infections in children in Europe (the EUCLIDS Project): a prospective cohort study

Federico Martinón-Torres1, Antonio Salas2, Irene Rivero-Calle1

  • 1Pediatrics Department, Translational Pediatrics and Infectious Diseases Section, Santiago de Compostela, Spain; Genetics- Vaccines- Infectious Diseases and Pediatrics research group GENVIP, Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain.

The Lancet. Child & Adolescent Health
|September 1, 2018
PubMed

Insights

Childhood sepsis and severe infections in Europe have low mortality, primarily affecting children under 5. Vaccine-preventable bacteria like meningococcus and pneumococcus are key culprits, yet pathogens remain unidentified in half of cases.

Area of Science:

  • Pediatric Infectious Diseases
  • Epidemiology
  • Public Health

Background:

  • Sepsis and severe focal infections pose a significant health challenge for hospitalized children.
  • Understanding the disease burden and outcomes of life-threatening bacterial infections in European children is crucial.

Purpose of the Study:

  • To investigate the disease burden and outcomes of life-threatening bacterial infections in children across Europe.
  • To identify common pathogens and risk factors associated with severe pediatric infections.

Main Methods:

  • A prospective, multicentre cohort study (EUCLIDS) was conducted in 6 European countries.
  • Recruited 2844 children (1 month to 18 years) with sepsis or severe focal infections between 2012 and 2015.
  • Collected demographic, clinical, and microbiological data via a web-based platform and local diagnostic procedures.

Main Results:

  • Sepsis occurred in 43.2% and severe focal infections in 56.8% of patients; the median age was 39.1 months.
  • Pneumonia, CNS infections, and skin/soft tissue infections were the most common syndromes.
  • Neisseria meningitidis, Staphylococcus aureus, and Streptococcus pneumoniae were the most frequent identified pathogens; overall mortality was 2.2%.

Conclusions:

  • Mortality for pediatric sepsis and severe focal infections in Europe is low, predominantly impacting children under 5.
  • Vaccine-preventable infections (meningococcal, pneumococcal) contribute significantly to the disease burden.
  • The causative organism remains unidentified in approximately 50% of cases, highlighting diagnostic challenges.
Abstract

More Related Videos

Studying Brain Function in Children Using Magnetoencephalography08:00

Studying Brain Function in Children Using Magnetoencephalography

Published on: April 8, 2019

9.6K
Measuring Attentional Biases for Threat in Children and Adults08:25

Measuring Attentional Biases for Threat in Children and Adults

Published on: October 19, 2014

15.8K

Related Concept Videos

Half-life of a Reaction02:42

Half-life of a Reaction

The half-life of a reaction (t1/2) is the time required for one-half of a given amount of reactant to be consumed. In each succeeding half-life, half of the remaining concentration of the reactant is consumed. For example, during the decomposition of hydrogen peroxide, during the first half-life (from 0.00 hours to 6.00 hours), the concentration of H2O2 decreases from 1.000 M to 0.500 M. During the second half-life (from 6.00 hours to 12.00 hours), the concentration decreases from 0.500 M to...
39.1K
Characteristics of Life01:23

Characteristics of Life

Biology is a natural science that studies life and living organisms, including their structure, function, development, interactions, evolution, distribution, and taxonomy. The field's scope is extensive and divided into several specialized disciplines, such as anatomy, physiology, ethology, genetics, and many more. All living things share a few key traits, including cellular organization, heritable genetic material and the ability to adapt/evolve, metabolism to regulate energy needs, the...
261.8K
Fischer Projections02:18

Fischer Projections

Learning to draw Fischer projections of molecules and understanding their relevance plays a crucial role in the visual depiction of organic molecules. A Fischer projection is a two-dimensional projection on a planar surface to simplify the three-dimensional wedge–dash representation of molecules. This is especially helpful in the case of molecules with multiple chiral centers that can be difficult to draw. Here, all the bonds of interest are represented as horizontal or vertical lines. While...
16.6K
The Angiosperm Life Cycle02:39

The Angiosperm Life Cycle

Plants have a life cycle split between two multicellular stages: a haploid stage—with cells containing one set of chromosomes—and a diploid stage—with cells containing two sets of chromosomes. The haploid stage is the gamete-producing gametophyte, and the diploid stage is the spore-producing sporophyte.
72.6K
Newman Projections02:06

Newman Projections

Different notations are used to represent the three-dimensional structure of molecules on two-dimensional surfaces. One of the most commonly used representations is the dash-wedge formula. The dashed wedges, solid wedges, and the plane lines indicate the groups situated behind the plane, coming out of the plane, and in the plane, respectively.
The organic molecules rotate across the single bonds leading to numerous temporary three-dimensional structures of varying energy known as...
21.1K
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
49.7K