Ultrasound Elastography Applications in Pediatrics

Vishal Thumar1, Judy H Squires2, Paul J Spicer3

  • 1University of Missouri-Kansas City School of Medicine, Kansas City, MO.

Ultrasound Quarterly
|September 1, 2018
PubMed

Insights

Ultrasound elastography shows promise in pediatric imaging, particularly for liver diseases and cerebral palsy muscle stiffness. Further research is needed for broader clinical application in pediatric small organ evaluation.

Area of Science:

  • Pediatric Radiology
  • Medical Imaging
  • Ultrasound Technology

Background:

  • Ultrasound is a key pediatric imaging tool due to its safety and accessibility.
  • Ultrasound elastography measures tissue stiffness, offering new diagnostic insights.
  • Pediatric imaging benefits from non-invasive techniques like elastography.

Purpose of the Study:

  • To review the performance of ultrasound elastography in pediatric pathology evaluation.
  • To highlight established and emerging applications of pediatric ultrasound elastography.
  • To assess the current clinical relevance and future potential of this technology.

Main Methods:

  • Literature review of studies on pediatric ultrasound elastography.
  • Analysis of elastography applications in various pediatric conditions.
  • Synthesis of findings on diagnostic accuracy and clinical utility.

Main Results:

  • Established applications include pediatric liver diseases (fibrosis, biliary atresia, hepatic congestion).
  • Promising musculoskeletal application: measuring muscle stiffness in cerebral palsy.
  • Early-stage research exists for other pediatric applications, requiring more investigation.

Conclusions:

  • Ultrasound elastography is a valuable tool in specific pediatric areas, notably liver and musculoskeletal conditions.
  • Further research and validation are essential for expanding its clinical use in pediatric small organ imaging.
  • Elastography holds significant potential for advancing non-invasive pediatric diagnostics.

Related Concept Videos

Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
704
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
266
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
314
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
236
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
305
Ultrasound I: Abdominal Ultrasonography01:20

Ultrasound I: Abdominal Ultrasonography

Introduction:
Abdominal ultrasonography, commonly known as abdominal ultrasound, is a vital, non-invasive medical imaging technique widely used in healthcare.
Procedure:
This diagnostic tool allows the clinician to visually inspect internal structures within the abdomen, including vital organs such as the liver, gallbladder, pancreas, kidneys, and spleen.
The abdominal ultrasound process begins with applying a special gel to the patient's skin over the abdomen. This gel enhances the...
1.7K