Related Experiment Video

Updated: Feb 5, 2026

'Boden Food Plate': Novel Interactive Web-based Method for the Assessment of Dietary Intake
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'Boden Food Plate': Novel Interactive Web-based Method for the Assessment of Dietary Intake

Published on: September 18, 2018

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Is there an effect of dietary intake on MS-related fatigue? - A systematic literature review

Uwe Martin Pommerich, John Brincks, Marie Ernst Christensen

    Multiple Sclerosis and Related Disorders
    |September 1, 2018
    PubMed
    Abstract

    Insights

    Dietary interventions may help manage fatigue in multiple sclerosis (MS). Adequate magnesium and folate intake showed potential benefits, but more research is needed to confirm these findings for persons with MS.

    Area of Science:

    • Neurology
    • Nutrition Science
    • Systematic Review Methodology

    Background:

    • Fatigue is the most prevalent symptom in multiple sclerosis (MS), affecting up to 90% of patients.
    • Current pharmacological treatments for MS-related fatigue offer limited efficacy.
    • Growing interest exists in dietary interventions for managing MS symptoms.

    Purpose of the Study:

    • To systematically review the impact of holistic dietary intake on fatigue perception in adults with MS.
    • To synthesize evidence from intervention trials on dietary patterns and MS fatigue.

    Main Methods:

    • Comprehensive literature search across seven major databases (Embase, Medline, Web of Science, etc.).
    • Inclusion of intervention trials focusing on holistic dietary regimens and subjective fatigue in adult MS patients.
    • Risk of bias assessment using a modified Downs and Black checklist.

    Main Results:

    • Four studies (one pilot trial, three RCTs) met inclusion criteria.
    • Dietary interventions included low-fat, low-fat/starchy plant food, and modified paleo diets (3-12 months).
    • Two studies reported significant fatigue improvements with adequate folate and magnesium intake.

    Conclusions:

    • Holistic dietary intake shows potential for reducing MS-related fatigue.
    • Evidence suggests a trend towards decreased fatigue with adequate magnesium and folate.
    • Further robust research is required to establish definitive conclusions.
    Keywords:
    Chronic illnessDietDietary intakeFatigueMultiple sclerosis

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