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According to Charles Cooley, we base our image on what we think other people see (Cooley 1902). We imagine how we must appear to others, then react to this speculation. We don certain clothes, prepare our hair in a particular manner, wear makeup, use cologne, and the like—all with the notion that our presentation of ourselves is going to affect how others perceive us. We expect a certain reaction, and, if lucky, we get the one we desire and feel good about it. But more than that, Cooley...
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Consider the elastic torsion formula, which applies to a circular shaft with a consistent cross-section. This formula assumes that the shaft's ends are loaded with rigid plates firmly attached. However, in many cases, torques are applied to the shaft through mechanisms like flange couplings or gears, which are connected by keys inserted into keyways. This application method modifies the stress distribution near the point of torque application, causing it to deviate from the distributions...
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CIRCpedia v2: An Updated Database for Comprehensive Circular RNA Annotation and Expression Comparison.

Rui Dong1, Xu-Kai Ma1, Guo-Wei Li1

  • 1CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Genomics, Proteomics & Bioinformatics
|September 2, 2018
PubMed
Summary

CIRCpedia v2 is a comprehensive database for circular RNA (circRNA) annotation across six species. It aids in understanding circRNA function and potential disease applications by providing expression data and analysis tools.

Keywords:
Back-splicingCIRCpediaCircRNACircular RNADatabase

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Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • Circular RNAs (circRNAs) are a class of RNA molecules formed by back-splicing.
  • They are broadly expressed in eukaryotes with tissue- and species-specific patterns.
  • While many circRNA functions are unknown, some regulate gene expression and are linked to diseases.

Purpose of the Study:

  • To update and expand the CIRCpedia database for comprehensive circRNA annotation.
  • To provide a resource for exploring circRNA expression across diverse samples and species.
  • To facilitate functional studies and clinical applications of circRNAs.

Main Methods:

  • Integration of over 180 RNA-sequencing datasets from six species.
  • Development of a web interface for searching, browsing, and downloading circRNA data.
  • Inclusion of conservation analysis between human and mouse circRNAs.
  • Incorporation of computational tools for circRNA expression comparison.

Main Results:

  • CIRCpedia v2 offers extensive annotation for circRNAs.
  • The database includes expression profiles across various cell types, tissues, and disease samples.
  • Conservation analysis and comparative expression tools are integrated.

Conclusions:

  • CIRCpedia v2 serves as a valuable resource for circRNA research.
  • The database supports the investigation of circRNA functions and their roles in diseases.
  • It facilitates the development of circRNAs as potential diagnostic biomarkers.