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Pharmacotherapy for amphetamine dependence: A systematic review.

Nicole K Lee¹, Linda Jenner², Angela Harney²

¹National Drug Research Institute, Curtin University, 7 Parker Place, Bentley, WA, 6102, Australia; 360Edge Consulting, P.O. Box 359, Elwood, 3184, Victoria, Australia.

Drug and Alcohol Dependence

|September 3, 2018

Summary

Currently, no medication effectively treats amphetamine use disorder. While some drugs show limited benefits, more research is needed to improve treatment engagement and adherence for amphetamine dependence.

Keywords:

Amphetamine Dependence Methamphetamine Pharmacotherapy Treatment

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Intracranial Pharmacotherapy and Pain Assays in Rodents

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Published on: April 9, 2019

Area of Science:

Pharmacology
Addiction Medicine
Clinical Trials

Background:

Amphetamine use disorder is a growing global health concern.
Effective pharmacotherapy can enhance treatment options and engagement in behavioral therapies for amphetamine dependence.

Purpose of the Study:

To identify medications with potential to improve treatment outcomes for individuals dependent on amphetamines.

Main Methods:

A comprehensive literature search was conducted across major databases (Medline, PsycINFO, Embase, Cochrane) from 1997 to 2016.
Studies on pharmacotherapies for amphetamine/methamphetamine dependence were selected and assessed.
A meta-narrative review approach was employed to synthesize findings from 49 eligible studies, including 33 randomized controlled trials (RCTs).

Main Results:

Twenty potential pharmacotherapies were investigated, with five showing limited evidence for reducing amphetamine use: methylphenidate, bupropion, modafinil, and naltrexone.
Dexamphetamine showed benefits in treatment retention but not in reducing amphetamine use.
Six other medications indicated potential efficacy, but insufficient studies preclude definitive conclusions.

Conclusions:

No single medication currently demonstrates sufficient and consistent evidence for routine treatment of amphetamine use disorder.
High rates of study dropout and poor medication adherence present significant challenges to evidence strength and clinical application.
Further research is crucial to identify effective strategies for improving patient engagement and treatment outcomes in pharmacotherapy for amphetamine dependence.