Nodular fasciitis of the tongue: A case report in an infant
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Updated: Feb 5, 2026

Fabrication of Tongue Extracellular Matrix and Reconstitution of Tongue Squamous Cell Carcinoma In Vitro
Published on: June 20, 2018
Raymond P Shupak1, Bruce B Horswell2, Marcus D Shaffer3
1University of Pittsburgh Medical Center -Department of Oral and Maxillofacial Surgery, Pittsburgh, PA, 15213, United States.
Abstract:
Nodular fasciitis is a benign lesion uncommonly found in the head and neck region. Although described previously in adults, there have been no reports of nodular fasciitis in a child's tongue. A 4 month old male infant was referred for evaluation of a rapidly growing tongue lesion. He underwent excisional biopsy of the lesion. Initial pathology suggested a spindle cell tumor. Subsequent outside facility molecular testing was obtained and Nodular Fasciitis was confirmed. Nodular fasciitis is a rare benign tumor that can be often mistaken for malignancy. Special histochemical and molecular testing is required to obtain final diagnosis.
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