Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)01:16

Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)

3.2K
Ring-opening metathesis polymerization or ROMP involves strained cycloalkenes as starting materials. The mechanism of ROMP proceeds by reacting cycloalkene with Grubbs catalyst to give metallacyclobutane intermediate which undergoes a ring-opening reaction to form new carbene. The new carbene reacts with another molecule of cycloalkene. Repetition of these steps leads to the formation of an unsaturated open-chain polymer product. All these steps are reversible, however, relieving the ring...
3.2K
Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)00:53

Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)

2.2K
Acyclic diene metathesis polymerization or ADMET polymerization involves cross-metathesis of terminal dienes, such as 1,8-nonadiene, to give linear unsaturated polymer and ethylene. As ADMET is a reversible process, the formed ethylene gas must be removed from the reaction mixture to complete the polymerization process.
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...
2.2K
Olefin Metathesis Polymerization: Overview01:13

Olefin Metathesis Polymerization: Overview

2.6K
Recently, the development of olefin metathesis polymerization advanced the field of polymer synthesis. Simply put, the reorganization of substituents on their double bonds between two olefins in the presence of a catalyst is known as the olefin metathesis reaction. The use of metathesis reaction for polymer synthesis is called olefin metathesis polymerization.
Ruthenium-based Grubbs catalyst is the most commonly used catalyst for olefin metathesis polymerization. Grubbs catalyst consists of a...
2.6K
Polymers02:34

Polymers

41.0K
The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the...
41.0K
Polymers02:34

Polymers

23.3K
23.3K
Enzymes02:34

Enzymes

94.9K
Inside living organisms, enzymes act as catalysts for many biochemical reactions involved in cellular metabolism. The role of enzymes is to reduce the activation energies of biochemical reactions by forming complexes with its substrates. The lowering of activation energies favor an increase in the rates of biochemical reactions.
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...
94.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Programming local confinements in crystalline frameworks through reticular chemistry.

Nature materials·2026
Same author

Programming local confinements in crystalline frameworks through reticular chemistry.

Nature materials·2026
Same author

The 2026 global roadmap for textile-integrated wearable technologies in health.

Physiological measurement·2026
Same author

Impact of BHT Additive on the Optical and Reactive Behavior of Fluorescent Peroxynitrite Probes.

ACS omega·2026
Same author

Reversible Addition-Fragmentation Chain-Transfer Aqueous Emulsion Polymerization Observed by Transmission Electron Microscopy.

Journal of the American Chemical Society·2026
Same author

Prediction of rheological properties via structure elucidation of solvated hydrogels.

Nature materials·2026

Related Experiment Video

Updated: Feb 5, 2026

Photogeneration of N-Heterocyclic Carbenes: Application in Photoinduced Ring-Opening Metathesis Polymerization
12:19

Photogeneration of N-Heterocyclic Carbenes: Application in Photoinduced Ring-Opening Metathesis Polymerization

Published on: November 29, 2018

9.0K

Enzyme-Responsive Polymer Nanoparticles via Ring-Opening Metathesis Polymerization-Induced Self-Assembly.

Daniel B Wright1, Matthew P Thompson1, Mollie A Touve1

  • 1Department of Chemistry, Department of Materials Science and Engineering, Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, Illinois, 60208-3113, USA.

Macromolecular Rapid Communications
|September 4, 2018
PubMed
Summary

This study introduces open-to-air ring-opening metathesis polymerization-induced self-assembly (ROMPISA) for creating peptide polymer nanoparticles. These nanoparticles respond to enzymes, forming larger structures, demonstrating a robust method for stimuli-responsive nanomaterials.

Keywords:
ROMPISAblock copolymerspeptidesself-assembly

More Related Videos

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery
09:09

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

Published on: May 2, 2019

8.0K
Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
06:47

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Published on: September 20, 2011

38.2K

Related Experiment Videos

Last Updated: Feb 5, 2026

Photogeneration of N-Heterocyclic Carbenes: Application in Photoinduced Ring-Opening Metathesis Polymerization
12:19

Photogeneration of N-Heterocyclic Carbenes: Application in Photoinduced Ring-Opening Metathesis Polymerization

Published on: November 29, 2018

9.0K
Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery
09:09

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

Published on: May 2, 2019

8.0K
Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
06:47

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Published on: September 20, 2011

38.2K

Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Nanotechnology

Background:

  • Peptide polymer nanoparticles offer unique properties for various applications.
  • Developing efficient and scalable methods for nanoparticle synthesis is crucial.
  • Stimuli-responsive nanomaterials require controlled assembly and disassembly mechanisms.

Purpose of the Study:

  • To report open-to-air aqueous-phase ring-opening metathesis polymerization-induced self-assembly (ROMPISA).
  • To prepare well-defined peptide polymer nanoparticles under ambient conditions.
  • To demonstrate the stimuli-responsive behavior of these nanoparticles.

Main Methods:

  • Utilizing aqueous-phase ring-opening metathesis polymerization-induced self-assembly (ROMPISA).
  • Conducting polymerization open-to-air at room temperature and high solids concentrations (10 w/w%).
  • Investigating nanoparticle rearrangement in the presence of the enzyme thermolysin.

Main Results:

  • Achieved control over molecular weight with high conversion during ROMPISA.
  • Successfully formed well-defined peptide polymer nanoparticles in open-air conditions.
  • Observed spontaneous rearrangement of nanoparticles into larger scaffolds upon enzyme addition.

Conclusions:

  • ROMPISA is a robust method for preparing stimuli-responsive nanostructures in one pot.
  • The developed method allows for nanoparticle formation under ambient conditions.
  • Peptide polymer nanoparticles exhibit enzyme-triggered self-assembly for scaffold formation.