Choroid Plexus Papilloma and Factor XIII Deficiency: Case Report

Area of Science:

• Neurology
• Hematology
• Pediatric Surgery

Background:

• Factor XIII deficiency is a rare inherited bleeding disorder.
• Diagnosis is challenging due to normal coagulation parameters in affected individuals.
• Clinical suspicion is key, especially with postsurgical bleeding or recurrent intracranial hematomas.

Observation:

• A case of an 8-month-old female with Factor XIII deficiency is presented.
• The patient experienced subdural hematoma after ventriculoperitoneal shunt surgery.
• Notably, no bleeding occurred after choroid plexus papilloma surgery.

Findings:

• Factor XIII deficiency can manifest as severe bleeding complications, including intracranial hemorrhage.
• The absence of bleeding after a second surgery suggests a potential protective effect or altered risk profile.
• This case highlights the diagnostic challenges and clinical importance of recognizing Factor XIII deficiency.

Implications:

• Timely diagnosis of Factor XIII deficiency is vital for neurologists and neurosurgeons.
• Accurate diagnosis can significantly reduce mortality and morbidity associated with bleeding disorders.
• This case underscores the need for heightened clinical awareness in pediatric patients with unexplained bleeding events.