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Adenovirus associated with acute diarrhea: a case-control study.
Fang-Zhou Qiu1,2, Xin-Xin Shen2, Gui-Xia Li3
1Hebei Medical University, Shijiazhuang, 050031, Hebei, China.
BMC Infectious Diseases
|September 5, 2018
Summary
Human adenoviruses (HAdV) are linked to childhood diarrhea. This study found non-enteric HAdV3 is also a significant cause of diarrhea in children, alongside HAdV species F (40, 41).
Area of Science:
- Virology
- Pediatrics
- Epidemiology
Background:
- Diarrhea causes significant childhood illness and death in low- and middle-income countries.
- Human adenoviruses (HAdV), particularly species F (HAdV-40, HAdV-41), are known causes of gastroenteritis.
- Limited data exist on the role of other HAdV serotypes in acute gastroenteritis.
Purpose of the Study:
- To investigate the association between non-enteric HAdV and diarrhea in children.
- To determine the prevalence and diversity of HAdV serotypes in diarrheal disease.
Main Methods:
- A case-control study was conducted with 273 children with diarrhea and 361 healthy controls.
- Quantitative real-time PCR (qPCR) was used to detect and quantify HAdV.
- Serotyping and phylogenetic analysis identified HAdV types, with Odds Ratios (OR) assessing risk.
Main Results:
- HAdV was detected in 28.94% of children with diarrhea and 7.20% of healthy controls.
- Dominant serotypes in diarrhea cases were HAdV-40, HAdV-41, and HAdV-3.
- HAdV-3 showed a significant association with diarrhea (adjusted OR = 9.205, p < 0.001), in addition to HAdV-40 and HAdV-41.
Conclusions:
- A wide diversity of HAdV serotypes circulates among children with and without diarrhea.
- Non-enteric HAdV-3 is implicated as a significant pathogen contributing to childhood diarrhea.
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