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Retzius-Sparing Robot-Assisted Radical Prostatectomy
Published on: May 19, 2022
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Robot assisted radical cystectomy versus open radical cystectomy in bladder cancer (RACE): study protocol of a
C J Wijburg1, C T J Michels2, J R Oddens3
1Department of Urology, Rijnstate Hospital, Wagnerlaan 55, 6815, AD, Arnhem, The Netherlands. Cwijburg@rijnstate.nl.
BMC Cancer
|September 5, 2018
Summary
Robot-assisted radical cystectomy (RARC) is increasingly used despite unproven cost-effectiveness. This trial compares RARC to open radical cystectomy (ORC) to determine the most effective and cost-effective surgical approach for bladder cancer.
Area of Science:
- Urology
- Surgical Oncology
- Health Economics
Background:
- Robot-assisted radical cystectomy (RARC) use is increasing, though its cost-effectiveness compared to open radical cystectomy (ORC) is not established.
- ORC remains the standard of care for high-risk non-muscle-invasive and muscle-invasive bladder cancer.
- A comparative effectiveness trial is needed to evaluate RARC versus ORC.
Purpose of the Study:
- To compare the cost-effectiveness of RARC versus ORC for bladder cancer treatment.
- To assess objective outcomes, including complication rates and oncological results.
- To evaluate patient-reported health-related quality of life.
Main Methods:
- Non-randomized, multicentre comparative effectiveness trial.
- 338 patients enrolled across 23 centres (12 ORC, 10 RARC, 1 LRC).
- Data collection includes clinical outcomes, quality of life questionnaires, and monthly resource usage for cost analysis.
- Propensity score matching used to adjust for baseline differences.
Main Results:
- Data collection ongoing for complication rates, oncological outcomes, and quality of life.
- Cost analysis will be performed using monthly resource usage data.
- Results will be presented as average differences between groups with 95% confidence intervals.
Conclusions:
- This study aims to provide evidence-based guidelines for radical cystectomy surgical techniques.
- Findings will inform clinical decision-making regarding the optimal approach for bladder cancer patients.
- The research will contribute to understanding the value of RARC in comparison to ORC.
Keywords:
Bladder cancerComplicationsCost-effectivenessQuality of lifeRadical cystectomyRobot-assistedMore Related Videos
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