Related Experiment Video

Updated: Feb 5, 2026

Imaging Spatial Reorganization of a MAPK Signaling Pathway Using the Tobacco Transient Expression System
08:54

Imaging Spatial Reorganization of a MAPK Signaling Pathway Using the Tobacco Transient Expression System

Published on: March 20, 2016

10.3K

Polysaccharide isolated from Phellinus linteus mycelia exerts anti-inflammatory effects via MAPK and PPAR signaling

Tao Hu1, Qinlu Lin1, Ting Guo1

  • 1Hunan Key Laboratory of Grain-Oil Deep Process and Quality Control, Hunan Key Laboratory of Processed Food for Special Medical Purpose, College of Food Science and Engineering, National Engineering Laboratory for Deep Process of Rice and Byproducts, Central South University of Forestry and Technology, Changsha, Hunan 41004, China.

Carbohydrate Polymers
|September 5, 2018
PubMed

Insights

Phellinus linteus polysaccharide (PLP) effectively reduced inflammation in mouse models by improving health and inhibiting inflammatory cytokines. PLP also modulated MAPK and PPAR pathways in cell models, revealing its anti-inflammatory mechanisms.

Area of Science:

  • Pharmacology
  • Immunology
  • Natural Products

Background:

  • Inflammation is a complex biological response implicated in various diseases.
  • Phellinus linteus is a medicinal mushroom with a history of traditional use.
  • Polysaccharides are known to possess diverse biological activities, including immunomodulatory effects.

Purpose of the Study:

  • To investigate the anti-inflammatory effects of Phellinus linteus polysaccharide (PLP).
  • To explore the underlying molecular mechanisms of PLP's anti-inflammatory action in both animal and cellular models.

Main Methods:

  • An animal model of colitis was induced using 2.0% dextran sulfate sodium (DSS) in ICR mice.
  • PLP was administered orally at 500 mg/kg/day to investigate its therapeutic potential.
  • A lipopolysaccharide (LPS)-induced inflammation cell model was used to elucidate the molecular pathways involved.

Main Results:

  • PLP administration significantly improved the health status of DSS-induced colitis mice.
  • PLP inhibited DSS-induced pathological alterations and reduced inflammatory cytokine expression in colonic tissues.
  • In LPS-induced cells, PLP reduced inflammatory cytokines, inhibited the MAPK pathway, and modulated NF-κB, AP-1, PPARα, and PPARγ signaling.

Conclusions:

  • Phellinus linteus polysaccharide (PLP) demonstrates significant anti-inflammatory properties.
  • The anti-inflammatory mechanism of PLP involves the modulation of MAPK and PPAR signaling pathways.
  • PLP effectively reduces the expression of key inflammatory cytokines, suggesting its therapeutic potential.
Keywords:
AP-1ColitisInflammationMAPKNF-κBPPARPhellinus linteuspolysaccharide (PLP)

More Related Videos

Effects of Taste Signaling Protein Abolishment on Gut Inflammation in an Inflammatory Bowel Disease Mouse Model09:31

Effects of Taste Signaling Protein Abolishment on Gut Inflammation in an Inflammatory Bowel Disease Mouse Model

Published on: November 9, 2018

9.1K
Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity07:09

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

8.0K

Related Concept Videos

MAPK Signaling Cascades01:07

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
8.4K
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.6K
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
10.1K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.4K
Biosynthesis of Polysaccharides01:26

Biosynthesis of Polysaccharides

Polysaccharides such as glycogen and starch are synthesized from nucleoside diphosphate sugars, primarily uridine diphosphate glucose (UDPG) and adenosine diphosphate glucose (ADPG). These activated glucose donors act as key intermediates in carbohydrate metabolism and biosynthesis. UDPG primarily involves glycogen synthesis in animals and many bacteria, while ADPG plays a fundamental role in starch synthesis in plants and certain bacteria.UDPG is formed when glucose-1-phosphate reacts with...
647
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
8.5K