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Updated: Feb 5, 2026

Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen
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RNA, Action through Interactions.

Tri C Nguyen1, Kathia Zaleta-Rivera1, Xuerui Huang1

  • 1Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.

Trends in Genetics : TIG
|September 5, 2018
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Summary
This summary is machine-generated.

Recent advances in RNA biology reveal novel functions of the noncoding genome. Transcriptome-wide analysis shows RNA

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Area of Science:

  • RNA Biology
  • Genomics
  • Molecular Biology

Background:

  • The human genome is pervasively transcribed, suggesting undiscovered functions for the noncoding genome.
  • Noncoding genome functions are often mediated by RNA transcripts, relying on structure and molecular interactions.
  • Traditional methods limited RNA studies to one molecule at a time.

Purpose of the Study:

  • To highlight recent technological advancements in transcriptome-wide RNA interaction analysis.
  • To showcase the expanded understanding of RNA's roles in cellular processes.

Main Methods:

  • Development of new technologies for transcriptome-wide mapping of RNA structures and interactions.
  • Application of these technologies to analyze RNA interactions in cultured cells and mouse brains.

Main Results:

  • Revealed extensive RNA-RNA interactions, including between transposon transcripts and messenger RNAs (mRNAs).
  • Identified noncoding RNAs associated with most human transcription start sites.
  • Demonstrated the versatility of RNA in diverse molecular systems.

Conclusions:

  • RNA plays critical roles in chromatin organization, gene regulation, and intracellular signaling.
  • Novel functions of the noncoding genome are being uncovered through advanced RNA analysis.
  • Current technologies enable a shift from single-RNA studies to comprehensive transcriptome-wide analyses.