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Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
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Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

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Genomic Profiling and Potentially Targetable Alterations in Pancreatic Ductal Adenocarcinoma

Ferga C Gleeson1, Michael J Levy2

  • 1Division of Gastroenterology & Hepatology, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA. Gleeson.ferga@mayo.edu.

Current Treatment Options in Gastroenterology
|September 5, 2018
PubMed
Abstract

Insights

Pancreatic cancer (PDAC) treatment is improving with precision oncology. Genomic insights are identifying tumor subtypes and guiding targeted therapies like PARP inhibitors and immunotherapies.

Area of Science:

  • Oncology
  • Genomics
  • Precision Medicine

Background:

  • Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis and limited response to conventional treatments.
  • Genomic advancements are revealing tumor subtypes and potential therapeutic targets.

Purpose of the Study:

  • To review the emerging role of precision oncology in identifying novel genomic information for PDAC treatment.
  • To explore the impact of tumor genotyping and gene expression assessments on treatment strategies.

Main Methods:

  • Review of current research in precision oncology for PDAC.
  • Analysis of emerging genomic data, including somatic and germline mutations.
  • Evaluation of tumor BRCA status and microsatellite instability.

Main Results:

  • Growing interest in BRCA status for PARP inhibitor therapy.
  • Identification of microsatellite instability in up to 3% of PDAC patients for immunotherapy.
  • Tumor genotyping and gene expression assessments offer new treatment avenues.

Conclusions:

  • Precision oncology offers new hope for effective PDAC treatment strategies.
  • Genomic profiling is crucial for guiding targeted therapies and immunotherapy eligibility.
  • Further research is needed to establish the impact of novel therapies like immuno-oncology and stroma-targeting agents.
Keywords:
BRCAImmune checkpoint inhibitorsImmuno-oncologyPARP inhibitorsPancreatic ductal adenocarcinomaRNA sequencingTumor microenvironment

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