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Related Concept Videos

Cis-regulatory Sequences02:02

Cis-regulatory Sequences

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Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
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Asthma-I: Introduction01:29

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
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Asthma-IV: Diagnostic and Management01:30

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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Related Experiment Video

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Acupuncture in a Rat Model of Asthma
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Regulatory T cells and asthma.

Sheng-Tao Zhao1,2, Chang-Zheng Wang1

  • 1Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.

Journal of Zhejiang University. Science. B
|September 5, 2018
PubMed
Summary
This summary is machine-generated.

Regulatory T cells (Tregs) offer potential for improved asthma treatments by modulating immune responses. Further research into Tregs could lead to better strategies for controlling allergic inflammation and enhancing immune tolerance in asthma patients.

Keywords:
Regulatory T cell; Asthma; Transforming growth factor β (TGF-β); Interleukin 10 (IL-10); IL-35

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Area of Science:

  • Immunology
  • Allergy and Asthma Research

Background:

  • Asthma involves chronic airway inflammation driven by T helper type 2 (Th2) cells.
  • Current glucocorticoid treatments manage inflammation but do not restore immune tolerance to allergens.

Purpose of the Study:

  • To review the classification, characteristics, and immunomodulatory mechanisms of regulatory T cells (Tregs).
  • To discuss the role and progress of Tregs in the context of asthma.
  • To highlight the potential of Tregs for novel asthma therapies.

Main Methods:

  • Literature review focusing on regulatory T cells (Tregs).
  • Analysis of Treg classification, biological characteristics, and differentiation.
  • Examination of Treg immunomodulatory functions and their relevance to asthma.

Main Results:

  • Regulatory T cells (Tregs) are key negative regulators of immune responses.
  • Tregs play a significant role in allergic diseases, including asthma.
  • Understanding Treg mechanisms is crucial for developing new therapeutic approaches.

Conclusions:

  • Regulatory T cells (Tregs) represent a promising therapeutic target for asthma.
  • Further investigation into Treg-mediated immune regulation can advance asthma treatment strategies.
  • Tregs may offer a pathway to restore immune tolerance in allergic asthma.