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Updated: Feb 5, 2026
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Author Spotlight: Characterizing Porous Materials for Aiding the Development of Robust Metal-Organic Frameworks with Adsorption Behavior
Published on: March 8, 2024
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Biocompatible porous metal-organic framework nanoparticles based on Fe or Zr for gentamicin vectorization
X Unamuno1, E Imbuluzqueta2, F Salles3
1Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy and Nutrition, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain; Institute Lavoisier, CNRS UMR 8180, Université de Versailles Saint-Quentin-en-Yvelines, 45 Avenue des Etats-Unis, 78035 Versailles Cedex, France.
Summary
Nanoscaled Metal-Organic Frameworks (nanoMOFs) effectively encapsulate gentamicin (GM), an antibiotic, improving its delivery. GM-loaded nanoMOFs show preserved antibacterial activity and low toxicity, offering a promising drug delivery system.
Area of Science:
- Materials Science
- Nanotechnology
- Pharmacology
Background:
- Nanoscaled Metal-Organic Frameworks (nanoMOFs) offer high porosity and tunable composition for drug delivery.
- Gentamicin (GM) antibiotic faces bioavailability and toxicity issues, necessitating improved delivery systems.
- Encapsulation of GM in nanoMOFs is explored to overcome limitations of free drug administration.
Purpose of the Study:
- To encapsulate Gentamicin (GM) into biocompatible iron and zirconium-based nanoMOFs.
- To characterize the resulting GM-loaded nanoMOFs using various analytical techniques.
- To evaluate the in vitro release, toxicity, and antibacterial efficacy of GM-loaded nanoMOFs.
Main Methods:
- Impregnation method for GM encapsulation into nanoMOFs (MIL-100(Fe)).
- Comprehensive characterization using XRPD, FTIR, TGA, N2 sorption, SEM, DLS, zeta-potential, fluorescence spectroscopy, and molecular simulations.
- In vitro release studies under simulated oral and intravenous conditions.
- In vitro cytotoxicity assays on THP-1 and NIH/3T3 cell lines.
- Antibacterial activity tests against S. aureus, S. epidermidis, and P. aeruginosa.
Main Results:
- High and reproducible GM encapsulation rates (up to 600 µg/mg) achieved with MIL-100(Fe) nanoMOFs.
- Complete GM release within 8h in protein-free media; slower release in protein-containing media.
- Low cytotoxicity of GM-loaded MIL-100(Fe) NPs (IC50 > 1 mg/mL).
- Preserved antibacterial activity of released GM, comparable to free GM.
Conclusions:
- Biocompatible MIL-100(Fe) nanoMOFs are effective carriers for Gentamicin (GM) delivery.
- GM-loaded nanoMOFs demonstrate controlled release, low toxicity, and maintained antibacterial efficacy.
- These nanoMOFs represent a promising platform for enhanced antibiotic drug delivery systems.
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