Metal organic frameworks based on bioactive components

Area of Science:

• Biomedical Engineering
• Materials Science
• Nanotechnology

Background:

• Metal-Organic Frameworks (MOFs) are increasingly explored for biomedical applications.
• Ensuring biosafety and activity is crucial for clinical translation.
• BioMOFs utilize endogenous or bioactive components for enhanced biocompatibility.

Purpose of the Study:

• To review recent advancements in 3D Metal Biomolecule Frameworks (bioMOFs).
• To categorize bioMOFs based on their active components.
• To highlight bioMOF applications in drug delivery, imaging, and sensing.

Main Methods:

• Literature review of recent studies on 3D bioMOFs.
• Classification of bioMOFs by their endogenous/bioactive building blocks.
• Analysis of synthesis strategies and biorelated activities.

Main Results:

• Successful construction of 3D bioMOFs using bioactive motifs.
• Demonstrated potential in drug delivery systems.
• Emerging applications in biomedical imaging and sensing.

Conclusions:

• BioMOFs represent a promising class of materials for diverse biomedical applications.
• The design of bioMOFs with tailored active components is key to their success.
• Further research will likely expand their therapeutic and diagnostic capabilities.