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Updated: Feb 5, 2026

Production and Detection of Reactive Oxygen Species ROS in Cancers
Published on: November 21, 2011
Benzothiazole carbamates and amides as antiproliferative species
Milica Videnović1, Marija Mojsin2, Milena Stevanović3
1Faculty of Chemistry Innovative Centre, Studentski Trg 12-16, 11158 Belgrade, Serbia.
Abstract:
A series of new benzothiazole-based carbamates and amides were synthesized and their antiproliferative activity was determined. Derivatives with profound activity were identified and further investigated for their possible mechanism of action. It was found that these compounds induce specific apoptosis, G2/M cell cycle arrest and decrease ROS level in MCF-7 human breast cancer cell line. Moreover, submicromolar antiproliferative activity of examined carbamates against NT2/D1 testicular embryonal carcinoma was shown. The most potent derivatives strongly inhibited NT2/D1 cell migration and invasiveness.
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