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Drugs for Treatment of Constipation-Predominant IBS01:21

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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Constipation-Associated Stercoral Colitis.

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This summary is machine-generated.

A pediatric fecaloma caused severe colitis in a 9-year-old girl, leading to hospitalization. Prompt manual disimpaction and supportive care resulted in a full recovery, highlighting the importance of timely intervention for fecal impaction.

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Area of Science:

  • Pediatric Gastroenterology
  • Colorectal Surgery

Background:

  • A 9-year-old girl with a history of constipation presented with stool incontinence.
  • She developed acute symptoms including nausea, emesis, and loose stools.

Observation:

  • Physical examination revealed hypotension, tachycardia, and abdominal tenderness.
  • Laboratory tests showed marked leukocytosis (66,000).

Findings:

  • Computed tomography (CT) scan identified a large fecaloma with colonic inflammation, consistent with stercoral colitis.
  • No infectious or other physiologic causes for constipation and colitis were identified.

Implications:

  • Urgent manual disimpaction and supportive care led to the child's recovery.
  • This case underscores the potential severity of fecal impaction in children and the need for prompt management.