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Updated: Feb 5, 2026

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
Published on: November 10, 2014
Major Complications Associated with Conventional Transbronchial Needle Aspiration.
Muhammad K Zaman1, Rabin Shrestha1
1From the Department of Pulmonary, Critical Care and Sleep Medicine, University of Tennessee Health Science Center, and the Veterans Affairs Medical Center, Memphis, Tennessee.
Complications from transbronchial needle aspiration (TBNA) are often underreported. Awareness and vigilance are crucial, especially for patients on anticoagulants, to minimize risks associated with this diagnostic procedure.
Area of Science:
- Pulmonology
- Interventional Pulmonology
- Diagnostic Bronchoscopy
Background:
- Transbronchial needle aspiration (TBNA) is a standard technique for diagnosing and staging airway lesions.
- Complications associated with conventional TBNA (C-TBNA) are not widely recognized or reported.
Purpose of the Study:
- To report the incidence and nature of complications following C-TBNA.
- To emphasize the importance of awareness and precautions during TBNA procedures.
Main Methods:
- A retrospective review of 606 consecutive C-TBNA cases performed between January 2003 and December 2016.
- Analysis focused on complications directly attributed to C-TBNA, excluding those from concurrent bronchoscopic techniques.
Main Results:
- Infectious complications can arise from the introduction of oropharyngeal bacteria into sterile spaces.
- Specific complication rates were assessed in the context of C-TBNA performance.
Conclusions:
- Complications related to TBNA are frequently underappreciated due to underreporting and lack of awareness.
- Heightened awareness, precaution, and vigilant monitoring are recommended for all patients undergoing TBNA, particularly those on anticoagulant or antiplatelet therapy.
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