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Updated: Feb 5, 2026
06:05
An In Vitro Approach to Study Mitochondrial Dysfunction: A Cybrid Model
Published on: March 9, 2022
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Mycotoxin-assisted mitochondrial dysfunction and cytotoxicity: Unexploited tools against proliferative disorders
Muhammad Torequl Islam1,2, Siddhartha Kumar Mishra3, Swati Tripathi4
1Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, 700000, Vietnam.
IUBMB Life
|September 5, 2018
Summary
Mycotoxins like citrinin, aflatoxin, and T-2 toxin disrupt cellular mitochondria, causing oxidative stress and cell death. This mitochondrial dysfunction links mycotoxins to chronic diseases and potential cancer therapies.
Area of Science:
- Biochemistry
- Toxicology
- Cell Biology
Background:
- Mitochondria are vital cellular components; their dysfunction is implicated in various diseases.
- Mycotoxins, fungal metabolites, possess diverse biological activities and can be toxic.
- Mycotoxins exhibit complex mechanisms of action, with potential therapeutic applications, including in cancer treatment.
Purpose of the Study:
- To analyze the impact of mycotoxins on mitochondrial dysfunction.
- To review current literature on mycotoxin-induced mitochondrial damage and its implications.
Main Methods:
- Comprehensive literature search of electronic databases (PubMed, ScienceDirect, Scopus, Web of Science, Google Scholar).
- Analysis of published studies detailing mycotoxin effects on mitochondrial function.
Main Results:
- Mycotoxins (e.g., citrinin, aflatoxin, T-2 toxin) induce mitochondrial dysfunction through multiple mechanisms.
- Oxidative stress and activation of apoptotic pathways are key consequences of mycotoxin exposure.
- Mycotoxin-induced mitochondrial dysfunction is linked to chronic diseases.
Conclusions:
- Mycotoxins can serve as lead compounds for developing chemotherapeutic agents due to their cytotoxic effects on cancer cells.
- Understanding mycotoxin-mediated mitochondrial dysfunction is crucial for disease pathology and therapeutic development.
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