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Computed tomography of monkey brain tumors
Journal of Computer Assisted Tomography
|September 1, 1986
Summary
Researchers developed a primate brain tumor model using Rous sarcoma virus in Japanese monkeys. Computed tomography (CT) effectively detected tumors and correlated with histopathology, showing promise for brain tumor research.
Area of Science:
- Neuroscience
- Oncology
- Radiology
Background:
- Developing reliable animal models is crucial for studying brain tumors.
- Computed tomography (CT) is a key imaging modality in neuro-oncology.
Purpose of the Study:
- To establish a primate model of induced brain tumors using Rous sarcoma virus.
- To evaluate the efficacy of computed tomography (CT) in detecting and characterizing these induced tumors.
Main Methods:
- Intracerebral inoculation of Japanese monkeys with Schmidt-Ruppin strain of Rous sarcoma virus.
- Tumor induction and monitoring using computed tomography (CT).
- Histopathological correlation of CT findings.
Main Results:
- Tumors were induced in 54.3% of inoculated monkeys.
- CT detected tumors in symptomatic animals with an average latency of 32.6 days.
- CT features correlated well with histopathological findings, including tumor, hemorrhage, necrosis, and edema.
Conclusions:
- The induced primate brain tumor model is suitable for CT studies.
- CT is effective in detecting and characterizing brain tumors in this model.
- The model's characteristics make it valuable for future brain tumor research.