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Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
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Urinary biomarkers for early detection of platinum based drugs induced nephrotoxicity

Mostafa Abdelsalam1, Ekramy Elmorsy2, Hassan Abdelwahab3

  • 1Mansoura Nephrology and dialysis Unit, Internal Medicine Department, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt. moustafaabdelsalam@yahoo.com.

BMC Nephrology
|September 6, 2018
PubMed
Abstract

Insights

Urinary biomarkers KIM-1, Cystatin C, and NGAL can detect platinum-based drug nephrotoxicity earlier than serum creatinine. KIM-1 demonstrates the highest sensitivity for early acute kidney injury detection in patients undergoing platinum-based drug therapy.

Area of Science:

  • Nephrology
  • Oncology
  • Biomarker Discovery

Background:

  • Platinum-based drugs (PBD) are crucial cancer therapeutics but can cause nephrotoxicity, limiting optimal dosing.
  • Serum creatinine is an inadequate biomarker for early detection of acute kidney injury (AKI) in patients receiving PBD.

Purpose of the Study:

  • To evaluate novel urinary biomarkers for early detection of PBD-induced AKI.
  • To compare the sensitivity of KIM-1, NGAL, and Cystatin C against serum creatinine for AKI prediction.

Main Methods:

  • A prospective cohort study included 132 patients receiving PBD.
  • AKI diagnosis followed KDIGO guidelines using serum creatinine.
  • Urinary biomarkers (KIM-1, NGAL, Cystatin C) and serum creatinine were measured during and after PBD cycles.

Main Results:

  • AKI developed in 35 patients (26.52%).
  • KIM-1, Cystatin C, and NGAL levels significantly increased on the day of AKI and one day prior.
  • KIM-1 showed a significant increase two days before serum creatinine rise in AKI patients.

Conclusions:

  • Urinary KIM-1, Cystatin C, and NGAL can predict PBD-induced AKI earlier than serum creatinine.
  • KIM-1 is the most sensitive biomarker for the early detection of AKI in patients receiving PBD.
Keywords:
CisplatinNephrotoxicityOxaplatinPlatinum based drugsUrinary biomarkers

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