Correlations of Post-stroke Depression with Inflammatory Response Factors

Area of Science:

• Neuroscience
• Immunology
• Clinical Medicine

Background:

• Post-stroke depression (PSD) is a common complication following stroke.
• Inflammatory response factors, including interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and high-sensitivity C-reactive protein (CRP), are implicated in various neurological and psychiatric conditions.

Purpose of the Study:

• To investigate the correlation between inflammatory response factors (IL-6, TNF-α, CRP) and the presence and severity of PSD.
• To identify potential biomarkers for PSD and inform treatment and prevention strategies.

Main Methods:

• Retrospective analysis of clinical laboratory data from 120 patients (60 with PSD, 60 without PSD).
• Comparison of inflammatory marker expression levels between groups using statistical methods.
• Multiple Logistic regression analysis to determine if inflammatory factors are independent risk factors for PSD.

Main Results:

• Patients with PSD exhibited significantly higher expression levels of IL-6, TNF-α, and CRP compared to those without PSD (P<0.001).
• Significant differences in IL-6, TNF-α, and CRP levels were observed among patients with mild, moderate, and severe PSD (P<0.05).
• IL-6, TNF-α, and CRP were identified as independent risk factors for PSD, with odds ratios of 1.160, 1.099, and 1.248, respectively.

Conclusions:

• The expression levels of IL-6, TNF-α, and CRP are significantly elevated in patients with PSD.
• These inflammatory markers are independent risk factors for developing PSD.
• Clinical control of IL-6, TNF-α, and CRP levels is vital for the effective treatment and prevention of PSD.