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Basophil Activation Test for Allergy Diagnosis

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Published on: May 31, 2021

Mammalian meat allergy.

Xin L Wong¹, Deshan F Sebaratnam¹

¹University of New South Wales, Kensington, NSW, Australia.

International Journal of Dermatology

|September 6, 2018

Summary

This summary is machine-generated.

Mammalian meat allergy involves IgE antibodies to galactose-α-1,3-galactose, causing symptoms like urticaria and anaphylaxis after eating red meat. Dermatologists should consider this emergent allergy in tick-endemic regions.

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Area of Science:

Immunology
Allergology
Dermatology

Background:

Mammalian meat allergy is an IgE-mediated hypersensitivity.
It is triggered by the oligosaccharide epitope galactose-α-1,3-galactose.
This allergy is increasingly recognized in tick-endemic areas.

Purpose of the Study:

To inform dermatologists about mammalian meat allergy.
To highlight its clinical presentation and diagnostic considerations.

Main Methods:

Review of clinical characteristics and immunological basis of mammalian meat allergy.
Emphasis on IgE antibody response to the galactose-α-1,3-galactose epitope.

Main Results:

Symptoms include urticaria, angioedema, gastroenteritis, and anaphylaxis.
Reactions occur hours after red meat consumption.
Cutaneous manifestations are common.

Conclusions:

Mammalian meat allergy is an emergent condition.
Dermatologists must include this allergy in their differential diagnosis for urticarial and anaphylaxis cases.
Awareness is crucial for timely diagnosis and management.