[Serum activity of CK and CK-MB in patients with dengue virus infection]
Ivony Y Agudelo-Salas1, Nini Quinceno2, Juliana Duque3
1IA: Bs.C. M. Sc. Instituto Colombiano de Medicina Tropical-Universidad CES, Sabaneta, Colombia. iyagudelo@ces.edu.co.
Insights
Patients with dengue infection often show elevated levels of creatine kinase (CK) and CK-myocardial band (CK-MB), indicating potential muscle involvement. Monitoring these enzymes is recommended for dengue patient care.
Area of Science:
- Cardiology
- Infectious Diseases
- Biochemistry
Background:
- Dengue infection is a significant public health concern.
- Cardiac and muscle involvement in dengue is not fully understood.
- Creatine kinase (CK) and CK-myocardial band (CK-MB) are biomarkers for muscle and cardiac injury.
Purpose of the Study:
- To determine serum activity of CK and CK-MB in dengue patients.
- To assess potential cardiac and skeletal muscle involvement during dengue infection.
Main Methods:
- Cross-sectional study in Antioquia, Colombia.
- Included 54 dengue patients and 10 healthy controls.
- Measured serum CK and CK-MB activity via blood samples.
Main Results:
- 50.9% of dengue patients had elevated CK-MB; none in controls.
- Elevated CK-MB observed in patients with bradycardia, tachycardia, and hypotension.
- 29.6% of dengue patients had elevated CK; 10% in controls.
- Elevated CK associated with symptoms like vomiting and abdominal pain.
Conclusions:
- No dengue patients presented with myocarditis or myositis.
- Increased CK and CK-MB levels suggest striated and cardiac muscle involvement in dengue.
- Monitoring CK and CK-MB is advised for dengue patient management.
Objective:
To determine the serum activity of CK and CK-MB in patients with dengue infection.
Methods:
A cross section study was conducted in the State of Antioquia, Colombia. The study population consisted in 54 patients with diagnosis of dengue infection and 10 healthy controls. A blood sample was taken from all participants to confirm dengue infection and to measure the activity of CK and CK-MB.
Results:
The median age of dengue cases was 18 years and the median age of healthy controls was 28.5 years. Half of dengue patients (50.9 %) had elevated levels of CK-MB, in contrast with the healthy controls in which none presented increase of this enzyme. No patient presented myocarditis; however, elevated CK-MB was observed in 33.3 %, 44.4 % and 40 % of cases with bradycardia, tachycardia and hypotension respectively. In 29.6 % of the dengue patients, high level of CK was detected, in contrast to 10 % in the control group. Activity of CK elevated was observed in dengue patients with symptoms such as vomiting, hematemesis and abdominal pain, 87.5 %, 60 % and 50 %, respectively.
Conclusions:
In this study, no patient with dengue infection had heart disease or myositis; however, the finding of a higher frequency of elevated level CK and CK-MB in the dengue patients compared to the control group suggests the involvement of the striated muscle and of the cardiac muscle in this group. For this reason, the monitoring of these enzymes should be considered as part of the monitoring of patients with dengue.
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