Related Experiment Video
Updated: Feb 5, 2026
10:16
Automated and High-throughput Microbial Monoclonal Cultivation and Picking Using the Single-cell Microliter-droplet Culture Omics System
Published on: March 14, 2025
1.4K
Automated rare single cell picking with the ALS cellcelector™.
Constantin Nelep1, Jens Eberhardt1
1ALS Automated Lab Solutions GmbH, Jena, Germany.
Summary
The ALS CellCelector™ system isolates pure single circulating tumor cells (CTCs) from blood samples. This technology enables high-purity CTC retrieval for accurate molecular analysis in various cancers.
Area of Science:
- Single-cell analysis
- Cancer research
- Biotechnology
Background:
- Isolating rare circulating tumor cells (CTCs) from blood for molecular analysis is challenging due to contamination.
- Existing enrichment systems often lack the purity required for downstream molecular assays.
Purpose of the Study:
- To introduce the ALS CellCelector™ system for high-purity single CTC isolation.
- To demonstrate the system's capability in retrieving pure CTCs from diverse cancer liquid biopsies.
Main Methods:
- The ALS CellCelector™ system automates the screening and picking of single cells or clusters.
- It processes samples from various upstream enrichment techniques, including cell culture plates, Petri dishes, and slides.
- The system ensures full documentation for standardization and reproducibility.
Main Results:
- The CellCelector™ achieved 100% pure single CTC isolation.
- Pure CTCs and clusters were successfully retrieved from liquid biopsies of breast, prostate, ovarian, colorectal, lung, and brain cancers.
- The system is compatible with both fixed and live cells.
Conclusions:
- The ALS CellCelector™ effectively addresses the challenge of pure CTC isolation from liquid biopsies.
- This automated system facilitates standardization and reproducibility in single CTC retrieval for molecular analysis.
- The technology supports advancements in liquid biopsy applications for various cancer types.
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