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RNA Structure

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...

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Related Experiment Video

Updated: Aug 6, 2025

Optical Tweezers to Study RNA-Protein Interactions in Translation Regulation

Optical Tweezers to Study RNA-Protein Interactions in Translation Regulation

Published on: February 12, 2022

Selecting New RNA Crystal Contacts.

Anastassia Gomez¹, Navtej Toor¹

¹Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.

Structure (London, England : 1993)

|September 6, 2018

Summary

This summary is machine-generated.

RNA crystallization is challenging due to the need for extensive sequence variant testing. Shoffner et al. (2018) developed an in crystallo selection method for rapidly creating new RNA crystal contacts.

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Sample Preparation for Mass Spectrometry-based Identification of RNA-binding Regions

Sample Preparation for Mass Spectrometry-based Identification of RNA-binding Regions

Published on: September 28, 2017

Area of Science:

Structural Biology
Biochemistry
Molecular Biology

Background:

RNA crystallization is crucial for determining RNA structures but remains challenging.
Identifying suitable crystal contacts often requires screening numerous RNA sequence variants.

Purpose of the Study:

To introduce a novel method for accelerating the discovery of RNA crystal contacts.
To overcome the limitations of traditional RNA crystallization screening.

Main Methods:

Development of an 'in crystallo' selection procedure.
Application of the method to rapidly generate new RNA crystal contacts.

Main Results:

Demonstration of a procedure for rapid generation of RNA crystal contacts.
Facilitation of the crystallization process for RNA molecules.

Conclusions:

The 'in crystallo' selection method significantly enhances the efficiency of obtaining RNA crystals.
This approach is valuable for structural studies of RNA molecules.